Influence of substratum surface morphologies on the structure of extracellular matrix on a honeycomb film

Sadaaki Yamamoto, Hiroshi Sunami, Masaru Tanaka, Yasutaka Matsuo, Kuniharu Ijiro, Shigeko Yamashita, Yuka Morita, Masatsugu Shimomura

Research output: Contribution to conferencePaperpeer-review

Abstract

The substratum surface morphology plays vital roles in cellular behavior such as adhesion, spreading, migration, proliferation and differentiation We investigated here the structure of a cellular adhesive protein, fibronectin (Fn) adsorbed on both spin-coated films (flat film) and honeycomb pattern films made of poly-ε-caprolactone by using atomic force microscope and confocal laser scanning microscope in relation to the role of the substratum surface morphology in cellular behavior. Although the adsorption saturated at mono-layer adsorption level on both substrates, the structure was inhomogeneous and depend on the surface morphology of substrates: Fn formed fibril-like aggregates on the flat films. Contrary, they adsorbed around the pores on the honeycomb films.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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