TY - JOUR
T1 - Influence of the bacterial phenotypes on the clinical manifestations in Klebsiella pneumoniae bacteremia patients
T2 - A retrospective cohort study
AU - Togawa, Atsushi
AU - Toh, Hiromi
AU - Onozawa, Kyoko
AU - Yoshimura, Michinobu
AU - Tokushige, Chiemi
AU - Shimono, Nobuyuki
AU - Takata, Tohru
AU - Tamura, Kazuo
PY - 2015/12/5
Y1 - 2015/12/5
N2 - Ninety-four episodes of Klebsiella pneumoniae bloodstream infection were identified at a university hospital in Japan. After excluding extended-spectrum beta lactamase-producing strains, 83 blood isolates from these patients were assayed in terms of their bacterial phenotypes such as the mucoid and hypermucoviscosity phenotypes. Bacterial phenotypes were correlated with the patients' clinical manifestations. The hypermucoviscosity phenotype was significantly associated with septic shock at the onset of infections (odds ratio, 15.92; 95% confidence interval, 1.27-468.12), but was not associated with liver abscess formation. Mortality was determined by the presence of septic shock. RmpA gene was associated with the induction of the hypermucoviscosity phenotype. These results reveal unique roles of bacterial phenotypes on the patient's clinical condition in K. pneumoniae bacteremia.
AB - Ninety-four episodes of Klebsiella pneumoniae bloodstream infection were identified at a university hospital in Japan. After excluding extended-spectrum beta lactamase-producing strains, 83 blood isolates from these patients were assayed in terms of their bacterial phenotypes such as the mucoid and hypermucoviscosity phenotypes. Bacterial phenotypes were correlated with the patients' clinical manifestations. The hypermucoviscosity phenotype was significantly associated with septic shock at the onset of infections (odds ratio, 15.92; 95% confidence interval, 1.27-468.12), but was not associated with liver abscess formation. Mortality was determined by the presence of septic shock. RmpA gene was associated with the induction of the hypermucoviscosity phenotype. These results reveal unique roles of bacterial phenotypes on the patient's clinical condition in K. pneumoniae bacteremia.
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U2 - 10.1016/j.jiac.2015.04.004
DO - 10.1016/j.jiac.2015.04.004
M3 - Article
C2 - 26002138
AN - SCOPUS:84952629872
VL - 21
SP - 531
EP - 537
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 7
ER -
