TY - JOUR
T1 - Influence of the wettability of different titanium surface topographies on initial cellular behavior
AU - Nishimura, Tomoko
AU - Ogino, Yoichiro
AU - Ayukawa, Yasunori
AU - Koyano, Kiyoshi
N1 - Funding Information:
This work was supported by JSPS Grant-in-Aid for Scientific Research (C) (26462924 and 17K11755). The authors would like to thank the Department of Biomaterials, Faculty of Dental Science, Kyushu University, for the analysis of surface physicochemical properties.
Publisher Copyright:
© 2018, Japanese Society for Dental Materials and Devices. All rights reserved.
PY - 2018
Y1 - 2018
N2 - This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.
AB - This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.
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U2 - 10.4012/dmj.2017-334
DO - 10.4012/dmj.2017-334
M3 - Article
C2 - 29669955
AN - SCOPUS:85050894609
VL - 37
SP - 650
EP - 658
JO - Dental Materials Journal
JF - Dental Materials Journal
SN - 0287-4547
IS - 4
M1 - dmj/2017-334
ER -