TY - JOUR
T1 - Influence of the wettability of different titanium surface topographies on initial cellular behavior
AU - Nishimura, Tomoko
AU - Ogino, Yoichiro
AU - Ayukawa, Yasunori
AU - Koyano, Kiyoshi
PY - 2018
Y1 - 2018
N2 - This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.
AB - This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.
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U2 - 10.4012/dmj.2017-334
DO - 10.4012/dmj.2017-334
M3 - Article
C2 - 29669955
AN - SCOPUS:85050894609
VL - 37
SP - 650
EP - 658
JO - Dental Materials Journal
JF - Dental Materials Journal
SN - 0287-4547
IS - 4
M1 - dmj/2017-334
ER -