Influence of the wettability of different titanium surface topographies on initial cellular behavior

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3 Citations (Scopus)

Abstract

This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.

Original languageEnglish
Article numberdmj/2017-334
Pages (from-to)650-658
Number of pages9
Journaldental materials journal
Volume37
Issue number4
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)

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