Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors

S. Yamasaki, H. Henzan, Y. Ohno, T. Yamanaka, T. Iino, Y. Itou, M. Kuroiwa, M. Maeda, N. Kawano, N. Kinukawa, Toshihiro Miyamoto, K. Nagafuji, K. Shimoda, S. Inaba, S. Hayashi, S. Taniguchi, T. Shibuya, H. Gondo, T. Otsuka, M. Harada

Research output: Contribution to journalArticle

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Abstract

We investigated effects of variations in the cellular composition of G-CSF-mobilized peripheral blood progenitor cell (G-PBPC) allografts on clinical outcomes of allogeneic PBPC transplantation. We retrospectively analyzed transplanted doses of various immunocompetent cells from 27 HLA-identical sibling donors in relation to engraftment, incidence of graft-versus-host disease (GVHD), and survival. Significant variability was documented in both absolute numbers and relative proportions of CD34+, CD2+, CD3+, CD4 high +, CD4+25+, CD8 high +, CD19+, CD56+, and CD56+16+ cells contained in these allografts. Stepwise Cox regression analysis revealed that the CD56+ cell dose was significantly inversely correlated with the incidence of GVHD. Thus, there was a significantly higher incidence of grade II acute GVHD in patients receiving a lower CD56+16+ cell dose (hazard ratio (HR) 0.0090; 95% confidence interval (CI), <0.00001-3.38; P=0.031), a higher incidence of chronic GVHD in those receiving allografts with a lower CD56+16+ to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.0007; P=0.0035), and a higher incidence of extensive chronic GVHD in those receiving allografts with a lower CD5 + to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.053; P=0.0083). These results suggest that CD56+ cells in G-PBPC allografts from HLA-identical sibling donors may play an important role in preventing the development of GVHD.

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalBone Marrow Transplantation
Volume32
Issue number5
DOIs
Publication statusPublished - Sep 1 2003

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Graft vs Host Disease
Granulocyte Colony-Stimulating Factor
Siblings
Blood Cells
Stem Cells
Allografts
Tissue Donors
Incidence
Confidence Intervals
Homologous Transplantation
Regression Analysis
Survival

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors. / Yamasaki, S.; Henzan, H.; Ohno, Y.; Yamanaka, T.; Iino, T.; Itou, Y.; Kuroiwa, M.; Maeda, M.; Kawano, N.; Kinukawa, N.; Miyamoto, Toshihiro; Nagafuji, K.; Shimoda, K.; Inaba, S.; Hayashi, S.; Taniguchi, S.; Shibuya, T.; Gondo, H.; Otsuka, T.; Harada, M.

In: Bone Marrow Transplantation, Vol. 32, No. 5, 01.09.2003, p. 505-510.

Research output: Contribution to journalArticle

Yamasaki, S, Henzan, H, Ohno, Y, Yamanaka, T, Iino, T, Itou, Y, Kuroiwa, M, Maeda, M, Kawano, N, Kinukawa, N, Miyamoto, T, Nagafuji, K, Shimoda, K, Inaba, S, Hayashi, S, Taniguchi, S, Shibuya, T, Gondo, H, Otsuka, T & Harada, M 2003, 'Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors', Bone Marrow Transplantation, vol. 32, no. 5, pp. 505-510. https://doi.org/10.1038/sj.bmt.1704165
Yamasaki, S. ; Henzan, H. ; Ohno, Y. ; Yamanaka, T. ; Iino, T. ; Itou, Y. ; Kuroiwa, M. ; Maeda, M. ; Kawano, N. ; Kinukawa, N. ; Miyamoto, Toshihiro ; Nagafuji, K. ; Shimoda, K. ; Inaba, S. ; Hayashi, S. ; Taniguchi, S. ; Shibuya, T. ; Gondo, H. ; Otsuka, T. ; Harada, M. / Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors. In: Bone Marrow Transplantation. 2003 ; Vol. 32, No. 5. pp. 505-510.
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abstract = "We investigated effects of variations in the cellular composition of G-CSF-mobilized peripheral blood progenitor cell (G-PBPC) allografts on clinical outcomes of allogeneic PBPC transplantation. We retrospectively analyzed transplanted doses of various immunocompetent cells from 27 HLA-identical sibling donors in relation to engraftment, incidence of graft-versus-host disease (GVHD), and survival. Significant variability was documented in both absolute numbers and relative proportions of CD34+, CD2+, CD3+, CD4 high +, CD4+25+, CD8 high +, CD19+, CD56+, and CD56+16+ cells contained in these allografts. Stepwise Cox regression analysis revealed that the CD56+ cell dose was significantly inversely correlated with the incidence of GVHD. Thus, there was a significantly higher incidence of grade II acute GVHD in patients receiving a lower CD56+16+ cell dose (hazard ratio (HR) 0.0090; 95{\%} confidence interval (CI), <0.00001-3.38; P=0.031), a higher incidence of chronic GVHD in those receiving allografts with a lower CD56+16+ to CD34+ ratio (HR <0.00001; 95{\%} CI <0.00001-0.0007; P=0.0035), and a higher incidence of extensive chronic GVHD in those receiving allografts with a lower CD5 + to CD34+ ratio (HR <0.00001; 95{\%} CI <0.00001-0.053; P=0.0083). These results suggest that CD56+ cells in G-PBPC allografts from HLA-identical sibling donors may play an important role in preventing the development of GVHD.",
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T1 - Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors

AU - Yamasaki, S.

AU - Henzan, H.

AU - Ohno, Y.

AU - Yamanaka, T.

AU - Iino, T.

AU - Itou, Y.

AU - Kuroiwa, M.

AU - Maeda, M.

AU - Kawano, N.

AU - Kinukawa, N.

AU - Miyamoto, Toshihiro

AU - Nagafuji, K.

AU - Shimoda, K.

AU - Inaba, S.

AU - Hayashi, S.

AU - Taniguchi, S.

AU - Shibuya, T.

AU - Gondo, H.

AU - Otsuka, T.

AU - Harada, M.

PY - 2003/9/1

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N2 - We investigated effects of variations in the cellular composition of G-CSF-mobilized peripheral blood progenitor cell (G-PBPC) allografts on clinical outcomes of allogeneic PBPC transplantation. We retrospectively analyzed transplanted doses of various immunocompetent cells from 27 HLA-identical sibling donors in relation to engraftment, incidence of graft-versus-host disease (GVHD), and survival. Significant variability was documented in both absolute numbers and relative proportions of CD34+, CD2+, CD3+, CD4 high +, CD4+25+, CD8 high +, CD19+, CD56+, and CD56+16+ cells contained in these allografts. Stepwise Cox regression analysis revealed that the CD56+ cell dose was significantly inversely correlated with the incidence of GVHD. Thus, there was a significantly higher incidence of grade II acute GVHD in patients receiving a lower CD56+16+ cell dose (hazard ratio (HR) 0.0090; 95% confidence interval (CI), <0.00001-3.38; P=0.031), a higher incidence of chronic GVHD in those receiving allografts with a lower CD56+16+ to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.0007; P=0.0035), and a higher incidence of extensive chronic GVHD in those receiving allografts with a lower CD5 + to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.053; P=0.0083). These results suggest that CD56+ cells in G-PBPC allografts from HLA-identical sibling donors may play an important role in preventing the development of GVHD.

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