Influences of dehydration and rehydration on the lubrication properties of phospholipid polymer-grafted cross-linked polyethylene

Seido Yarimitsu, Toru Moro, Masayuki Kyomoto, Kenichi Watanabe, Sakae Tanaka, Kazuhiko Ishihara, Teruo Murakami

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Surface modification by grafting of biocompatible phospholipid polymer onto the surface of artificial joint material has been proposed to reduce the risk of aseptic loosening and improve the durability. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted cross-linked polyethylene (CLPE) has shown promising results for reducing wear of CLPE. The main lubrication mechanism for the PMPC layer is considered to be the hydration lubrication. In this study, the lubrication properties of PMPC-grafted CLPE were evaluated in reciprocating friction test with rehydration process by unloading in various lubricants. The start-up friction of PMPC-grafted CLPE was reduced, and the damage of PMPC layer was suppressed by rehydration in water or hyaluronic acid solutions. In contrast, the start-up friction of PMPC-grafted CLPE increased in fetal bovine serum solution, and the damage for PMPC layer was quite noticeable. Interestingly, the start-up friction of PMPC-grafted CLPE was reduced in fetal bovine serum solution containing hyaluronic acid, and the damage of the PMPC layer was suppressed. These results indicate that the rehydration by unloading and hyaluronic acid are elemental in maximizing the lubrication effect of hydrated PMPC layer.

Original languageEnglish
Pages (from-to)506-514
Number of pages9
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume229
Issue number7
DOIs
Publication statusPublished - Jul 3 2015

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

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