Inhibition by haloperidol, of adenosine 5'-triphosphate-evoked responses in rat pheochromocytoma cells

Schuichi Koizumi, Makoto Ikeda, Ken Nakazawa, Kaori Inoue, Kanako Ito, Kazuhide Inoue

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of haloperidol, a typical antipsychotic drug, on adenosine 5'-triphosphate (ATP)-induced increase in intracellular Ca2+ concentration ([Ca]i) and inward currents were investigated using rat pheochromocytoma PC12 cells. Haloperidol (10-100 μM) significantly attenuated the rise in [Ca]i evoked by 30 μM ATP. This inhibition was not mimicked by (-)-sulpiride, an antagonist to dopamine D2-receptor. Dopamine or other dopaminergic agents did not affect the [Ca]i rise evoked by ATP. Under whole-cell voltage-clamp, haloperidol inhibited the ATP-activated current in the cells. These results suggest that haloperidol inhibits the ATP-receptor/channel, leading to the attenuation of the ATP-evoked increase in [Ca]i. Mechanisms involving dopamine receptors may not contribute to the inhibition by haloperidol.

Original languageEnglish
Pages (from-to)624-630
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume210
Issue number2
DOIs
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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