The effect of imipramine on the ATP-evoked release of dopamine was analyzed in parallel with its effects on the rise in the intracellular Ca2+ concentration ([Ca2+](i)) and current induced by ATP in rat pheochromocytoma PC12 cells. Imipramine (10-300 μM) inhibited the ATP-evoked release of dopamine and rise in [Ca2+l(i) in a concentration-dependent fashion though the effect of imipramine on the release was slightly more obvious. Imipramine also inhibited the ATP-activated inward current at a similar concentration range. These results show a new pharmacological profile of imipramine, namely the inhibition of P2X2 receptors.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Mar 17 1998|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology