Inhibition by imipramine of ATP-evoked responses in rat pheochromocytoma cells

Schuichi Koizumi, Hisayuki Uneyama, Makoto Ikeda, Sinya Ueno, Kazuhide Inoue

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of imipramine on the ATP-evoked release of dopamine was analyzed in parallel with its effects on the rise in the intracellular Ca2+ concentration ([Ca2+](i)) and current induced by ATP in rat pheochromocytoma PC12 cells. Imipramine (10-300 μM) inhibited the ATP-evoked release of dopamine and rise in [Ca2+l(i) in a concentration-dependent fashion though the effect of imipramine on the release was slightly more obvious. Imipramine also inhibited the ATP-activated inward current at a similar concentration range. These results show a new pharmacological profile of imipramine, namely the inhibition of P2X2 receptors.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume244
Issue number2
DOIs
Publication statusPublished - Mar 17 1998
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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