Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa

Chiyono Okudaira, Yoko Ikeda, Shinichi Kondo, Shigeki Furuya, Yoshio Hirabayashi, Takashi Koyano, Yoshio Saito, Kazuo Umezawa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Sphingomyelinase is considered to be involved in the regulation of apoptosis and cell growth. In the course of our screening for acidic sphingomyelinase inhibitors we isolated three xanthone compounds, α-mangostin, cowanin, and cowanol, from the bark of Garcinia speciosa. These compounds competitively inhibited bovine brain-derived acidic sphingomyelinase with IC50 values of 14.1, 19.2, and 10.9 μM, respectively and inhibited the acidic sphingomyelinase more effectively than the neutral sphingomyelinase of bovine brain. α-Mangostin inhibited the acidic sphingomyelinase in the most selective manner. α-Mangostin was chemically modified and its structure-activity relationships are discussed.

Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalJournal of Enzyme Inhibition
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine

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    Okudaira, C., Ikeda, Y., Kondo, S., Furuya, S., Hirabayashi, Y., Koyano, T., Saito, Y., & Umezawa, K. (2000). Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa. Journal of Enzyme Inhibition, 15(2), 129-138. https://doi.org/10.1080/14756360009030346