Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose

Yoshiko Miura, Chouga You, Reiko Ohnishi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.

Original languageEnglish
Article number024407
JournalScience and Technology of Advanced Materials
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

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Trehalose
Amyloid
Agglomeration
Assays
Sugar Alcohols
Cytotoxicity
Sugars
Peptides
Atomic force microscopy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose. / Miura, Yoshiko; You, Chouga; Ohnishi, Reiko.

In: Science and Technology of Advanced Materials, Vol. 9, No. 2, 024407, 01.04.2008.

Research output: Contribution to journalArticle

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