Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose

Yoshiko Miura, Chouga You, Reiko Ohnishi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.

Original languageEnglish
Article number024407
JournalScience and Technology of Advanced Materials
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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