Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers

Yoshiko Miura, Kiyofumi Yamamoto, Kikuko Yasuda, Yoshihiro Nishida, Kazukiyo Kobayashi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Glycopolymers carrying sulfate saccharides were found to suppress the formation of amyloid fibrils by amyloid beta peptides, as evaluated by fluorescence assay of thioflavin T and AFM. CD spectra showed that the conformation of amyloid beta peptides was changed from beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.

Original languageEnglish
Title of host publicationCIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
PublisherTrans Tech Publications Ltd
Pages166-169
Number of pages4
ISBN (Print)9783908158141
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008 - Acireale, Sicily, Italy
Duration: Jun 8 2008Jun 13 2008

Publication series

NameCIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
Volume57

Other

Other3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008
CountryItaly
CityAcireale, Sicily
Period6/8/086/13/08

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering
  • Mechanics of Materials
  • Materials Science(all)

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