Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers

Yoshiko Miura; Kiyofumi Yamamoto; Kikuko Yasuda; Yoshihiro Nishida; Kazukiyo Kobayashi

doi:10.4028/www.scientific.net/AST.57.166

Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers

Yoshiko Miura, Kiyofumi Yamamoto, Kikuko Yasuda, Yoshihiro Nishida, Kazukiyo Kobayashi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Glycopolymers carrying sulfate saccharides were found to suppress the formation of amyloid fibrils by amyloid beta peptides, as evaluated by fluorescence assay of thioflavin T and AFM. CD spectra showed that the conformation of amyloid beta peptides was changed from beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.

Original language	English
Title of host publication	CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
Publisher	Trans Tech Publications Ltd
Pages	166-169
Number of pages	4
ISBN (Print)	9783908158141
DOIs	https://doi.org/10.4028/www.scientific.net/AST.57.166
Publication status	Published - 2008
Externally published	Yes
Event	3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008 - Acireale, Sicily, Italy Duration: Jun 8 2008 → Jun 13 2008

Publication series

Name	CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
Volume	57

Other

Other	3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008
Country/Territory	Italy
City	Acireale, Sicily
Period	6/8/08 → 6/13/08

All Science Journal Classification (ASJC) codes

Biotechnology
Biomedical Engineering
Mechanics of Materials
Materials Science(all)

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10.4028/www.scientific.net/AST.57.166

Cite this

Miura, Y., Yamamoto, K., Yasuda, K., Nishida, Y., & Kobayashi, K. (2008). Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers. In CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering (pp. 166-169). (CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering; Vol. 57). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/AST.57.166

Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers. / Miura, Yoshiko; Yamamoto, Kiyofumi; Yasuda, Kikuko et al.
CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering. Trans Tech Publications Ltd, 2008. p. 166-169 (CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering; Vol. 57).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Miura, Y, Yamamoto, K, Yasuda, K, Nishida, Y & Kobayashi, K 2008, Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers. in CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering. CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, vol. 57, Trans Tech Publications Ltd, pp. 166-169, 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008, Acireale, Sicily, Italy, 6/8/08. https://doi.org/10.4028/www.scientific.net/AST.57.166

Miura Y, Yamamoto K, Yasuda K, Nishida Y, Kobayashi K. Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers. In CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering. Trans Tech Publications Ltd. 2008. p. 166-169. (CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering). doi: 10.4028/www.scientific.net/AST.57.166

Miura, Yoshiko ; Yamamoto, Kiyofumi ; Yasuda, Kikuko et al. / Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers. CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering. Trans Tech Publications Ltd, 2008. pp. 166-169 (CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering).

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Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers

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