Inhibition of Alzheimer amyloid aggregation with sulfated gycopolymers

Yoshiko Miura, Kikuko Yasuda, Kiyofumi Yamamoto, Mihoko Koike, Yoshihiro Nishida, Kazukiyo Kobayashi

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79 Citations (Scopus)

Abstract

Glycopolymers carrying sulfated saccharides with modest sugar contents (11% and 28%) were found to suppress the formation of amyloid fibrils by amyloid β peptides (Aβ(1-42), Aβ(1-40), and Aβ(25-35)), as evaluated by thioflavin T assays and atomic force microscopy observation. Circular dichroism spectra showed that the conformation of amyloid β peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.

Original languageEnglish
Pages (from-to)2129-2134
Number of pages6
JournalBiomacromolecules
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Miura, Y., Yasuda, K., Yamamoto, K., Koike, M., Nishida, Y., & Kobayashi, K. (2007). Inhibition of Alzheimer amyloid aggregation with sulfated gycopolymers. Biomacromolecules, 8(7), 2129-2134. https://doi.org/10.1021/bm0701402