Inhibition of amyloid aggregation by polymers containing glycosaminoglycan sulfonate side groups

Yoshiko Miura; Shogo Sakamoto; Tomohiro Fukuda; Nobuhiko Yui

doi:10.1295/koron.69.47

Inhibition of amyloid aggregation by polymers containing glycosaminoglycan sulfonate side groups

Yoshiko Miura, Shogo Sakamoto, Tomohiro Fukuda, Nobuhiko Yui

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).

Original language	English
Pages (from-to)	47-53
Number of pages	7
Journal	KOBUNSHI RONBUNSHU
Volume	69
Issue number	1
DOIs	https://doi.org/10.1295/koron.69.47
Publication status	Published - Jan 1 2012

All Science Journal Classification (ASJC) codes

Chemical Engineering (miscellaneous)
Materials Science (miscellaneous)
Environmental Science(all)
Polymers and Plastics

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10.1295/koron.69.47

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abstract = "Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).",

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AU - Sakamoto, Shogo

AU - Fukuda, Tomohiro

AU - Yui, Nobuhiko

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N2 - Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).

AB - Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).

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Inhibition of amyloid aggregation by polymers containing glycosaminoglycan sulfonate side groups

Abstract

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