Inhibition of amyloid aggregation by polymers containing glycosaminoglycan sulfonate side groups

Yoshiko Miura, Shogo Sakamoto, Tomohiro Fukuda, Nobuhiko Yui

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polyrotaxanes carrying 6-sulfo-GlcNAc (PRX-6S-GlcNAc) were synthesized, and the inhibitory effect on amyloid β (Aβ) aggregation was investigated. Polyrotaxane with 10% sugar content showed a stronger inhibitory effect on Aβ aggregation than monomeric 6S-GlcNAc. The inhibitory effect on Aβ aggregation depends on the sugar content of the polyrotaxane and the amount of added polyrotaxane. Polyrotaxanes with lower 6S-GlcNAc content showed a better inhibitory effect, and the addition of larger amounts of PRX-6S-GlcNAc inhibited amyloid formation. Saccharide-modified polyrotaxane showed a smaller inihibitory effect than the glycopolymer carrying 6-sulfo-GlcNAc. The inhibitory effect of polyrotaxane on Aβ aggregation was investigated by atomic force microscopy (AFM).

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalKOBUNSHI RONBUNSHU
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

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