Inhibition of environmental estrogen-induced proliferation of human breast carcinoma MCF-7 cells by flavonoids

D. H. Han, H. Tachibana, K. Yamada

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36 Citations (Scopus)

Abstract

In the present study, we evaluated the individual and combined effects of environmental estrogens and flavonoids on the proliferation of human breast carcinoma MCF-7 cells. These compounds are as follows: (1) pharmaceutical chemicals such as diethylstilbestrol, 17α-ethynylestradiol (17ES), tamoxifen, mestranol, and clomiphene, (2) industrial chemicals such as bisphenol A (BisA), 4-octylphenol (OP), 4-nonylphenol (NP), and p, p′-biphenol, and (3) flavonoids such as daidzein (D), genistein (G), quercetin (Q), and luteolin (L). We found that nanomolar concentrations of 17ES, BisA, OP, and NP were sufficient to stimulate the proliferation of MCF-7 cells. Among them, 1 μM BisA exhibited cell proliferation-stimulating activity as strong as 10 nM 17β-estradiol; and D and G exhibited cell proliferation-stimulating activity at 10 nM. On the other hand, Q and L exhibited cell proliferation-inhibiting activity. We also found that 10 nM flavonoids, such as D, G, Q, and L, were able to inhibit the proliferation-stimulating activity in MCF-7 cells by 1 μM environmental estrogens.

Original languageEnglish
Article numberBF02577543
Pages (from-to)275-282
Number of pages8
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume37
Issue number5
DOIs
Publication statusPublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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