Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice

Rei Naitoh, Kazumasa Miyawaki, Norio Harada, Wataru Mizunoya, Kentaro Toyoda, Tohru Fushiki, Yuichiro Yamada, Yutaka Seino, Nobuya Inagaki

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Abstract

Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation in peripheral tissues under high-fat diet (HFD), but the mechanism is unknown. In the present study, we investigated the effects of inhibition of GIP signaling on adiponectin levels after 3 weeks of HFD by comparing wild-type (WT) mice and GIP receptor-deficient (Gipr-/-) mice. In HFD-fed Gipr-/- mice, fat oxidation was significantly increased and adiponectin mRNA levels in white adipose tissue and plasma adiponectin levels were significantly increased compared to those in HFD-fed WT mice. In addition, the PPARα mRNA level was increased and the ACC mRNA level was decreased in skeletal muscle of HFD-fed Gipr-/- mice compared with those in HFD-fed WT mice. These results indicate that inhibition of GIP signaling increases adiponectin levels, resulting in increased fat oxidation in peripheral tissues under HFD.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume376
Issue number1
DOIs
Publication statusPublished - Nov 7 2008

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Naitoh, R., Miyawaki, K., Harada, N., Mizunoya, W., Toyoda, K., Fushiki, T., Yamada, Y., Seino, Y., & Inagaki, N. (2008). Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice. Biochemical and Biophysical Research Communications, 376(1), 21-25. https://doi.org/10.1016/j.bbrc.2008.08.052