Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia

Neuroscience

• Apoptosis 100%
• Ischemia 83%
• Caspase 3 66%
• Poly ADP Ribose Polymerase 66%
• Caspase 1 66%
• Memory 50%
• Spatial Memory 50%
• Hippocampus 16%
• Interleukin 1 16%
• Dipeptidyl Carboxypeptidase 16%
• Glucopyranosyl Lipid A 16%
• Radial Arm Maze 16%
• Memory Disorder 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Apoptosis 100%
• Ischemia 66%
• Interleukin 1beta Converting Enzyme 66%
• Caspase 3 50%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 50%
• Drug 33%
• Rat 33%
• Interleukin 1 16%
• Glucopyranosyl Lipid A 16%
• Dipeptidyl Carboxypeptidase 16%
• Brain Ischemia 16%
• Occlusion 16%
• Memory Disorder 16%
• Caspase 3 Inhibitor 16%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 16%