Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report

Junko Hiroki, Yoshihiro Fukumoto, Hiroaki Shimokawa, Yoshitaka Hirooka, Akira Takeshita

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    An 86-year-old woman was admitted with unstable angina pectoris. Plain old balloon angioplasty (POBA) was performed for 90% stenosis at segment 7 of the left coronary artery with concomitant treatment with nitrate, calcium antagonists, and nicorandil. Five days after POBA, she again suffered chest pain at rest with ST depression by electrocardiography, despite increased doses of calcium-antagonist and nicorandil. Coronary arteriography showed no evidence of restenosis (50%) at the POBA site. The involvement of coronary artery spasm was considered and intravenous treatment with a Rho-kinase inhibitor, fasudil, was started, which resulted in disappearance of the anginal attacks. She refused to continue the fasudil treatment on day 5, which resulted in reappearance of anginal attacks. Third coronary angiography showed a 90% restenosis at POBA site and percutaneous coronary intervention was again performed. This case suggests that a Rho-kinase inhibitor is potentially effective to prevent anginal attacks in spastic angina.

    Original languageEnglish
    Pages (from-to)161-164
    Number of pages4
    JournalJournal of Cardiology
    Volume44
    Issue number4
    Publication statusPublished - Oct 2004

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

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