Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report

Junko Hiroki, Yoshihiro Fukumoto, Hiroaki Shimokawa, Yoshitaka Hirooka, Akira Takeshita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An 86-year-old woman was admitted with unstable angina pectoris. Plain old balloon angioplasty (POBA) was performed for 90% stenosis at segment 7 of the left coronary artery with concomitant treatment with nitrate, calcium antagonists, and nicorandil. Five days after POBA, she again suffered chest pain at rest with ST depression by electrocardiography, despite increased doses of calcium-antagonist and nicorandil. Coronary arteriography showed no evidence of restenosis (50%) at the POBA site. The involvement of coronary artery spasm was considered and intravenous treatment with a Rho-kinase inhibitor, fasudil, was started, which resulted in disappearance of the anginal attacks. She refused to continue the fasudil treatment on day 5, which resulted in reappearance of anginal attacks. Third coronary angiography showed a 90% restenosis at POBA site and percutaneous coronary intervention was again performed. This case suggests that a Rho-kinase inhibitor is potentially effective to prevent anginal attacks in spastic angina.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalJournal of Cardiology
Volume44
Issue number4
Publication statusPublished - Oct 1 2004

Fingerprint

rho-Associated Kinases
Balloon Angioplasty
Muscle Spasticity
Nicorandil
Coronary Vessels
Unstable Angina
Spasm
Percutaneous Coronary Intervention
Coronary Angiography
Chest Pain
Angiography
Electrocardiography
Pathologic Constriction
Therapeutics
Calcium
fasudil

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hiroki, J., Fukumoto, Y., Shimokawa, H., Hirooka, Y., & Takeshita, A. (2004). Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report. Journal of Cardiology, 44(4), 161-164.

Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina : A case report. / Hiroki, Junko; Fukumoto, Yoshihiro; Shimokawa, Hiroaki; Hirooka, Yoshitaka; Takeshita, Akira.

In: Journal of Cardiology, Vol. 44, No. 4, 01.10.2004, p. 161-164.

Research output: Contribution to journalArticle

Hiroki, J, Fukumoto, Y, Shimokawa, H, Hirooka, Y & Takeshita, A 2004, 'Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report', Journal of Cardiology, vol. 44, no. 4, pp. 161-164.
Hiroki J, Fukumoto Y, Shimokawa H, Hirooka Y, Takeshita A. Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina: A case report. Journal of Cardiology. 2004 Oct 1;44(4):161-164.
Hiroki, Junko ; Fukumoto, Yoshihiro ; Shimokawa, Hiroaki ; Hirooka, Yoshitaka ; Takeshita, Akira. / Inhibition of Rho-kinase by fasudil prevents anginal attacks associated with spastic angina : A case report. In: Journal of Cardiology. 2004 ; Vol. 44, No. 4. pp. 161-164.
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