Inhibition of tyrosinase by flavonoids, stilbenes and related 4- substituted resorcinols: Structure-activity investigations

Kuniyoshi Shimizu, Ryuichiro Kondo, Kokki Sakai

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4- substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalPlanta medica
Volume66
Issue number1
DOIs
Publication statusPublished - Feb 26 2000

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Resorcinols
Stilbenes
Monophenol Monooxygenase
Flavonoids
Skeleton
Artocarpus
Agaricales
Structure-Activity Relationship
Alanine
Oxidation
Kinetics

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Inhibition of tyrosinase by flavonoids, stilbenes and related 4- substituted resorcinols : Structure-activity investigations. / Shimizu, Kuniyoshi; Kondo, Ryuichiro; Sakai, Kokki.

In: Planta medica, Vol. 66, No. 1, 26.02.2000, p. 11-15.

Research output: Contribution to journalArticle

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