Abstract
Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4- substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 11-15 |
| Number of pages | 5 |
| Journal | Planta medica |
| Volume | 66 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 26 2000 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
Inhibition of tyrosinase by flavonoids, stilbenes and related 4- substituted resorcinols : Structure-activity investigations. / Shimizu, Kuniyoshi; Kondo, Ryuichiro; Sakai, Kokki.
In: Planta medica, Vol. 66, No. 1, 26.02.2000, p. 11-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of tyrosinase by flavonoids, stilbenes and related 4- substituted resorcinols
T2 - Structure-activity investigations
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
AU - Sakai, Kokki
PY - 2000/2/26
Y1 - 2000/2/26
N2 - Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4- substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.
AB - Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4- substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.
UR - http://www.scopus.com/inward/record.url?scp=0033975767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033975767&partnerID=8YFLogxK
U2 - 10.1055/s-2000-11113
DO - 10.1055/s-2000-11113
M3 - Article
C2 - 10705726
AN - SCOPUS:0033975767
VL - 66
SP - 11
EP - 15
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 1
ER -