A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.
|Title of host publication||Bacterial Signal Transduction|
|Subtitle of host publication||Networks and Drug Targets|
|Number of pages||8|
|Publication status||Published - Dec 1 2008|
|Name||Advances in Experimental Medicine and Biology|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)