Inhibitors targeting two-component signal transduction

Takafumi Watanabe, Ario Okada, Yasuhiro Gotoh, Ryutaro Utsumi

Research output: Chapter in Book/Report/Conference proceedingChapter

27 Citations (Scopus)

Abstract

A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

Original languageEnglish
Title of host publicationBacterial Signal Transduction
Subtitle of host publicationNetworks and Drug Targets
EditorsRyutaro Utsumi
Pages229-236
Number of pages8
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume631
ISSN (Print)0065-2598

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Signal transduction
Signal Transduction
Anti-Bacterial Agents
Drug Discovery
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Watanabe, T., Okada, A., Gotoh, Y., & Utsumi, R. (2008). Inhibitors targeting two-component signal transduction. In R. Utsumi (Ed.), Bacterial Signal Transduction: Networks and Drug Targets (pp. 229-236). (Advances in Experimental Medicine and Biology; Vol. 631). https://doi.org/10.1007/978-0-387-78885-2_16

Inhibitors targeting two-component signal transduction. / Watanabe, Takafumi; Okada, Ario; Gotoh, Yasuhiro; Utsumi, Ryutaro.

Bacterial Signal Transduction: Networks and Drug Targets. ed. / Ryutaro Utsumi. 2008. p. 229-236 (Advances in Experimental Medicine and Biology; Vol. 631).

Research output: Chapter in Book/Report/Conference proceedingChapter

Watanabe, T, Okada, A, Gotoh, Y & Utsumi, R 2008, Inhibitors targeting two-component signal transduction. in R Utsumi (ed.), Bacterial Signal Transduction: Networks and Drug Targets. Advances in Experimental Medicine and Biology, vol. 631, pp. 229-236. https://doi.org/10.1007/978-0-387-78885-2_16
Watanabe T, Okada A, Gotoh Y, Utsumi R. Inhibitors targeting two-component signal transduction. In Utsumi R, editor, Bacterial Signal Transduction: Networks and Drug Targets. 2008. p. 229-236. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-0-387-78885-2_16
Watanabe, Takafumi ; Okada, Ario ; Gotoh, Yasuhiro ; Utsumi, Ryutaro. / Inhibitors targeting two-component signal transduction. Bacterial Signal Transduction: Networks and Drug Targets. editor / Ryutaro Utsumi. 2008. pp. 229-236 (Advances in Experimental Medicine and Biology).
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