Inhibitory adaptors in lymphocytes

Sho Yamasaki, Takashi Saito

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The negative regulation of lymphocyte activation and function is mediated by inhibition of signaling through antigen-receptor, co-stimulation receptor or cytokine receptor. The suppression of downstream signaling through antigen-receptor is mediated by negative regulators including adaptors and effectors such as phosphatases. "Inhibitory adaptors" exhibit their inhibitory function directly or indirectly by the localization to the vicinity of the antigen-receptor on the membrane. The strategy of inhibition by inhibitory adaptors includes the recruitment of inhibitory effector molecules, sequestration of positive regulators, internalization/degradation of receptor complexes, and the blockade of the dynamic movement of positive regulators.

    Original languageEnglish
    Pages (from-to)421-427
    Number of pages7
    JournalSeminars in Immunology
    Volume16
    Issue number6
    DOIs
    Publication statusPublished - Dec 2004

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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