Inhibitory adaptors in lymphocytes

Sho Yamasaki, Takashi Saito

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The negative regulation of lymphocyte activation and function is mediated by inhibition of signaling through antigen-receptor, co-stimulation receptor or cytokine receptor. The suppression of downstream signaling through antigen-receptor is mediated by negative regulators including adaptors and effectors such as phosphatases. "Inhibitory adaptors" exhibit their inhibitory function directly or indirectly by the localization to the vicinity of the antigen-receptor on the membrane. The strategy of inhibition by inhibitory adaptors includes the recruitment of inhibitory effector molecules, sequestration of positive regulators, internalization/degradation of receptor complexes, and the blockade of the dynamic movement of positive regulators.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalSeminars in Immunology
Volume16
Issue number6
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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