Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

Enos Tangke Arung; Eri Matsubara; Irawan Wijaya Kusuma; Edi Sukaton; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.fitote.2010.09.008

Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

Enos Tangke Arung, Eri Matsubara, Irawan Wijaya Kusuma, Edi Sukaton, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

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Abstract

In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

Original language	English
Pages (from-to)	198-202
Number of pages	5
Journal	Fitoterapia
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.fitote.2010.09.008
Publication status	Published - Mar 2011

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1016/j.fitote.2010.09.008

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title = "Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells",

abstract = "In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.",

author = "{Tangke Arung}, Enos and Eri Matsubara and {Wijaya Kusuma}, Irawan and Edi Sukaton and Kuniyoshi Shimizu and Ryuichiro Kondo",

note = "Funding Information: This research supported by Japan Society for the Promotion of Science (JSPS) for Postdoctoral Fellow of Foreign Researchers.",

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AU - Tangke Arung, Enos

AU - Matsubara, Eri

AU - Wijaya Kusuma, Irawan

AU - Sukaton, Edi

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

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AB - In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

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Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

Abstract

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