Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

Enos Tangke Arung, Eri Matsubara, Irawan Wijaya Kusuma, Edi Sukaton, Kuniyoshi Shimizu, Ryuichiro Kondo

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Abstract

In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalFitoterapia
Volume82
Issue number2
DOIs
Publication statusPublished - Mar 2011

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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