Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells

Kenichi Sogawa, Tomoki Sumida, Hiroyuki Hamakawa, Takahisa Yamada, Kozo Matsumoto, Masahiro Matsuda, Hironobu Oda, Hidenori Miyake, Seiki Tashiro, Koichi Okutani

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

An extracellular polysaccharide from marine microalga, dinoflagellate Gymnodinium sp. A3 (GA3), showed cytotoxicity to human myeloid leukemia K562 cells. We measured telomerase activity in K562 cells cultured with GA3 polysaccharide. 10.0 μg/ml of GA3 polysaccharide inhibited the telomerase activity in the cells completely. Also, we found a decrease in expression of the catalytic subunit of protein phosphatase (PP) type 1, PP1γ1, in K562 cells cultured with GA3 polysaccharide.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume99
Issue number3
Publication statusPublished - Mar 1 1998

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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