An extracellular polysaccharide from marine microalga, dinoflagellate Gymnodinium sp. A3 (GA3), showed cytotoxicity to human myeloid leukemia K562 cells. We measured telomerase activity in K562 cells cultured with GA3 polysaccharide. 10.0 μg/ml of GA3 polysaccharide inhibited the telomerase activity in the cells completely. Also, we found a decrease in expression of the catalytic subunit of protein phosphatase (PP) type 1, PP1γ1, in K562 cells cultured with GA3 polysaccharide.
|Number of pages||7|
|Journal||Research Communications in Molecular Pathology and Pharmacology|
|Publication status||Published - Mar 1 1998|
All Science Journal Classification (ASJC) codes
- Molecular Medicine