Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

Enos Tangke Arung; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1248/bpb.29.1966

Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

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79 Citations (Scopus)

Abstract

In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.

Original language	English
Pages (from-to)	1966-1969
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	9
DOIs	https://doi.org/10.1248/bpb.29.1966
Publication status	Published - Sept 12 2006

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/bpb.29.1966

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Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

Abstract

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