Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations

Yuzo Kayamori, Yoshiaki Katayama, Yasuhiro Kohama, Tsutomu Mimura, Naoko Sakaguchi, Hiroko Tsuboi, Norihito Murayama, Masahiko Itoh, Keishi Tanaka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The anti-inflammatory profile of the analogues of bis(2-aminopropyl) disulfide dihydrochloride with butyl (compd. II) and phenyl (compd. III) instead of the methyl group was studied in several mouse models related to phagocyte functions. The test samples were administered 2—3 h before the inflammatory stimulation or the peak of inflammation. Subcutaneously administered, compds. II and III significantly inhibited serotonin-induced paw edema in a dose-dependent manner (50% inhibitory dose values: 10 and 5 mg/kg, respectively), when orally administered at 25 mg/kg, these compounds were significantly effective, but their potencies were weaker. Neither compound had any irritant activity when administered at a dose of 12.5 pg/5 into the paw. In a sheep red blood cells (SRBC)-induced delayed-type hypersensitivity (DTH) reaction model, compd. II (25 mg/kg, s.c.) significantly inhibited the DTH responses when administered at two different times in relation to the time of challenge. However, there was only slight inhibition by compd. III (25 mg/kg, s.c.) on paw edema formation when administered 14 h after secondary immune response. In a model of experimental acute hepatic failure induced by successive injections of Propionibacterium acnes and lipopolysaccharide, both compounds increased mouse survived, compared with the control mice, and kept the serum levels of components involved in hepatic failure to nearly normal levels. These results demonstrate that compds. II and III possess an inhibitory effect on inflammation related to phagocytes.

Original languageEnglish
Pages (from-to)3013-3016
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number11
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

Delayed Hypersensitivity
Phagocytes
Inflammation
Edema
Propionibacterium acnes
Acute Liver Failure
Irritants
Liver Failure
Disulfides
Lipopolysaccharides
Serotonin
Sheep
Blood
Anti-Inflammatory Agents
Theoretical Models
Erythrocytes
Cells
Injections
Serum
bis(1-thio-2-amino-3-phenylpropane)

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations. / Kayamori, Yuzo; Katayama, Yoshiaki; Kohama, Yasuhiro; Mimura, Tsutomu; Sakaguchi, Naoko; Tsuboi, Hiroko; Murayama, Norihito; Itoh, Masahiko; Tanaka, Keishi.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 11, 01.01.1992, p. 3013-3016.

Research output: Contribution to journalArticle

Kayamori, Y, Katayama, Y, Kohama, Y, Mimura, T, Sakaguchi, N, Tsuboi, H, Murayama, N, Itoh, M & Tanaka, K 1992, 'Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations', Chemical and Pharmaceutical Bulletin, vol. 40, no. 11, pp. 3013-3016. https://doi.org/10.1248/cpb.40.3013
Kayamori, Yuzo ; Katayama, Yoshiaki ; Kohama, Yasuhiro ; Mimura, Tsutomu ; Sakaguchi, Naoko ; Tsuboi, Hiroko ; Murayama, Norihito ; Itoh, Masahiko ; Tanaka, Keishi. / Inhibitory Effect of Bis(2-aminohexyl) Disulfide and Bis(2-amino-3-phenylpropyl) Disulfide on Several Mouse Inflammations. In: Chemical and Pharmaceutical Bulletin. 1992 ; Vol. 40, No. 11. pp. 3013-3016.
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