The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in, vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferse activity.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Sep 30 1991|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology