TY - JOUR
T1 - Inhibitory effect of cadmium and mercury ions on transcription of the ada gene
AU - Suzuki, Makoto
AU - Takahashi, Kazuhiko
AU - Kawazoe, Yutaka
AU - Sakumi, Kunihiko
AU - Sekiguchi, Mutsuo
PY - 1991/9/30
Y1 - 1991/9/30
N2 - The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in, vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferse activity.
AB - The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in, vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferse activity.
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U2 - 10.1016/0006-291X(91)91744-W
DO - 10.1016/0006-291X(91)91744-W
M3 - Article
C2 - 1930191
AN - SCOPUS:0025936192
SN - 0006-291X
VL - 179
SP - 1517
EP - 1521
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -