Inhibitory effect of cadmium and mercury ions on transcription of the ada gene

Makoto Suzuki, Kazuhiko Takahashi, Yutaka Kawazoe, Kunihiko Sakumi, Mutsuo Sekiguchi

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The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in, vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferse activity.

Original languageEnglish
Pages (from-to)1517-1521
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Sep 30 1991


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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