Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus

Tomomi Shindou; Tomomi Shindou; Shuichi Koizumi; Yasufumi Kataoka; Kenji Yamamoto; Hiroshi Nakanishi

doi:10.1254/jjp.58.79

Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus

Tomomi Shindou, Tomomi Shindou, Shuichi Koizumi, Yasufumi Kataoka, Kenji Yamamoto, Hiroshi Nakanishi

Oral Biological Sciences

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Abstract

The effect of N-mcthyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This inhibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	the japanese journal of pharmacology
Volume	58
Issue number	1
DOIs	https://doi.org/10.1254/jjp.58.79
Publication status	Published - Jan 1992

All Science Journal Classification (ASJC) codes

Pharmacology

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abstract = "The effect of N-mcthyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This inhibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.",

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T1 - Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus

AU - Shindou, Tomomi

AU - Koizumi, Shuichi

AU - Kataoka, Yasufumi

AU - Yamamoto, Kenji

AU - Nakanishi, Hiroshi

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AB - The effect of N-mcthyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This inhibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.

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Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus

Abstract

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