Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines

Mitsuyo Noguchi, Masatoshi Yokoyama, Sumiko Watanabe, Michiko Uchiyama, Yoshifumi Nakao, Kouichi Hara, Tsuyoshi Iwasaka

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

To investigate the effect of (-)-epigallocatechin gallate (EGCG) on cervical adenocarcinoma, we performed a cell proliferation assay. TRAP assay is used for telomerase activity, flow cytometry analysis and pKi-67 immunofluoroscein staining in cervical adenocarcinoma cell lines (OMC-4, TMCC-1). Our results showed that EGCG inhibited the proliferation assay, TRAP assay for telomerase activity of both cell lines. Although cell apoptosis was induced, we observed that the expression of pKi-67 was suppressed. Our data suggest that EGCG may be effective for the treatment of cervical adenocarcinoma. The mechanisms of the anti-tumor effects were revealed to be the inhibition of telomerase activity, the induction of apoptosis and cell cycle dysregulation.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalCancer Letters
Volume234
Issue number2
DOIs
Publication statusPublished - Mar 28 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines'. Together they form a unique fingerprint.

Cite this