Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Flandiana Yogianti, Makoto Kunisada, Eiji Nakano, Ryusuke Ono, Sakumi Kunihiko, Sugako Oka, Yusaku Nakabeppu, Chikako Nishigori

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Reactive oxygen species produced in response to UVR are important in skin tumor development. We have previously reported that deficiency of the Ogg1 gene, encoding the repair enzyme for 8-oxo-7,8-dihydroguanine (8-oxoG), increases skin tumor incidence in mice upon repetitive UVB exposure and modulation of UVB-induced inflammatory response. Spirulina platensis is used as a human food supplement because it contains abundant nutritional and antioxidant components. Therefore, we investigated the inhibitory effects of S. platensis on UVB-induced skin tumor development in Ogg1 knockout-(KO) mice and the wild-type (WT) counterpart. Dietary S. platensis suppressed tumor induction and development in both genotypes compared with our previous data without S. platensis. Induction of erythema and ear swelling, one of the hallmarks of UVB-induced inflammatory responses, was suppressed in the skin of Ogg1-KO mice and albino hairless mice fed with dietary S. platensis. Compared with untreated mice, S. platensis-administered mice showed significantly reduced 8-oxoG formation in the skin after UVB exposure. Moreover, we found that S. platensis effectively downregulated the signal proteins p38 mitogen-activated protein kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and extracellular signal-regulated kinase after UVB exposure especially in Ogg1-KO mice. Our results suggest that S. platensis exerts antitumor effects against UVB irradiation in the skin through its anti-inflammatory and antioxidant effects.

Original languageEnglish
Pages (from-to)2610-2619
Number of pages10
JournalJournal of Investigative Dermatology
Volume134
Issue number10
DOIs
Publication statusPublished - Jan 1 2014

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Spirulina
Skin
Carcinogenesis
Tumors
Neoplasms
Antioxidants
Hairless Mouse
Gene encoding
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Erythema
Dietary Supplements
Heat-Shock Proteins
Knockout Mice
Protein Kinases
Ear
Swelling
Reactive Oxygen Species
Repair

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis. / Yogianti, Flandiana; Kunisada, Makoto; Nakano, Eiji; Ono, Ryusuke; Kunihiko, Sakumi; Oka, Sugako; Nakabeppu, Yusaku; Nishigori, Chikako.

In: Journal of Investigative Dermatology, Vol. 134, No. 10, 01.01.2014, p. 2610-2619.

Research output: Contribution to journalArticle

Yogianti, Flandiana ; Kunisada, Makoto ; Nakano, Eiji ; Ono, Ryusuke ; Kunihiko, Sakumi ; Oka, Sugako ; Nakabeppu, Yusaku ; Nishigori, Chikako. / Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis. In: Journal of Investigative Dermatology. 2014 ; Vol. 134, No. 10. pp. 2610-2619.
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