Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals

Seiko Kitahara, Shinichi Ito, Yuji Motono, Yoshimi Ikemoto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We investigated the effects of pentobarbital on the intracellular Ca2+concentration ([Ca2+]i) of the presynaptic nerve terminals (boutons). In the presence of external Ca2+, glutamate increased [Ca2+]i both in the neurons and in the presynaptic terminals. Pentobarbital suppressed the increase in neurons and in boutons with greater effects on the boutons. Our results indicated that pentobarbital may modulate the neurotransmission by inhibiting the transmitter release, which is induced by glutamate.

Original languageEnglish
Pages (from-to)269-270
Number of pages2
JournalInternational Congress Series
Volume1283
DOIs
Publication statusPublished - Nov 1 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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