INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia

Koshi Mimori, Heroshi Inoue, Hideshi Ishii, Masaki Mori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, much interest have been focused on the role of INI-1 a partner gene of transfusion protein All-1 for leukemogenesis of acute leukemia cases. We found the presence of a mutation at codon 152 in INI-1 that resulted in a conservative amino acid change in cDNA and genomic DNA from an AML patient. We also found the known polymorphic nucleotide change at the third letter of codon 299 in exon 7 of INI-1 in 3 of 31 ALL cases and in 4 of 30 AML cases. In conclusion, INI-1, a partner gene for ALL-1, is considered to be highly conserved in acute leukemia cases.

Original languageEnglish
Pages (from-to)551-553
Number of pages3
JournalOncology reports
Volume10
Issue number3
Publication statusPublished - May 1 2003

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Codon
Leukemia
Genes
Exons
Nucleotides
Complementary DNA
Amino Acids
Mutation
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia. / Mimori, Koshi; Inoue, Heroshi; Ishii, Hideshi; Mori, Masaki.

In: Oncology reports, Vol. 10, No. 3, 01.05.2003, p. 551-553.

Research output: Contribution to journalArticle

Mimori, Koshi ; Inoue, Heroshi ; Ishii, Hideshi ; Mori, Masaki. / INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia. In: Oncology reports. 2003 ; Vol. 10, No. 3. pp. 551-553.
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