INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia

Koshi Mimori, Heroshi Inoue, Hideshi Ishii, Masaki Mori

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1 Citation (Scopus)

Abstract

Recently, much interest have been focused on the role of INI-1 a partner gene of transfusion protein All-1 for leukemogenesis of acute leukemia cases. We found the presence of a mutation at codon 152 in INI-1 that resulted in a conservative amino acid change in cDNA and genomic DNA from an AML patient. We also found the known polymorphic nucleotide change at the third letter of codon 299 in exon 7 of INI-1 in 3 of 31 ALL cases and in 4 of 30 AML cases. In conclusion, INI-1, a partner gene for ALL-1, is considered to be highly conserved in acute leukemia cases.

Original languageEnglish
Pages (from-to)551-553
Number of pages3
JournalOncology reports
Volume10
Issue number3
Publication statusPublished - May 1 2003

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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