Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

Jun Ichi Suzuki, Hiroshi Ito, Ryo Gotoh, Ryuichi Morishita, Kensuke Egashira, Mitsuaki Isobe

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Nuclear factor-κB (NF-κB) plays a pivotal role in restenosis after percutaneous coronary intervention (PCI) and the aim of the present clinical trials was to evaluate the effectiveness of a NF-κB decoy for preventing restenosis. Methods and Results: The initial case was a patient suffering from effort angina who had stenoses in the proximal and middle portions of the right coronary artery. The patient received 2 stents; the NF-κB decoy was delivered to the distal site, but not the proximal site. Six months after the PCI, the NF-κB decoy had suppressed restenosis in comparison with the no-decoy transfection site. The second case was a patient who underwent single-stent insertion and decoy transfection at the same site, and minimal intimal thickening was observed at 6 month after PCI. No systemic adverse effects were observed in either case. Conclusion: These results indicate the clinical usefulness and safety of NF-κB decoy transfection after PCI, but further evaluations are necessary to confirm its clinical effectiveness.

Original languageEnglish
Pages (from-to)270-271
Number of pages2
JournalCirculation Journal
Volume68
Issue number3
DOIs
Publication statusPublished - Mar 1 2004

Fingerprint

Percutaneous Coronary Intervention
Transfection
Stents
Tunica Intima
Coronary Vessels
Pathologic Constriction
Clinical Trials
Safety

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis. / Suzuki, Jun Ichi; Ito, Hiroshi; Gotoh, Ryo; Morishita, Ryuichi; Egashira, Kensuke; Isobe, Mitsuaki.

In: Circulation Journal, Vol. 68, No. 3, 01.03.2004, p. 270-271.

Research output: Contribution to journalArticle

Suzuki, Jun Ichi ; Ito, Hiroshi ; Gotoh, Ryo ; Morishita, Ryuichi ; Egashira, Kensuke ; Isobe, Mitsuaki. / Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis. In: Circulation Journal. 2004 ; Vol. 68, No. 3. pp. 270-271.
@article{b2f5be0ba6d6412b821998bc50de574a,
title = "Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis",
abstract = "Background: Nuclear factor-κB (NF-κB) plays a pivotal role in restenosis after percutaneous coronary intervention (PCI) and the aim of the present clinical trials was to evaluate the effectiveness of a NF-κB decoy for preventing restenosis. Methods and Results: The initial case was a patient suffering from effort angina who had stenoses in the proximal and middle portions of the right coronary artery. The patient received 2 stents; the NF-κB decoy was delivered to the distal site, but not the proximal site. Six months after the PCI, the NF-κB decoy had suppressed restenosis in comparison with the no-decoy transfection site. The second case was a patient who underwent single-stent insertion and decoy transfection at the same site, and minimal intimal thickening was observed at 6 month after PCI. No systemic adverse effects were observed in either case. Conclusion: These results indicate the clinical usefulness and safety of NF-κB decoy transfection after PCI, but further evaluations are necessary to confirm its clinical effectiveness.",
author = "Suzuki, {Jun Ichi} and Hiroshi Ito and Ryo Gotoh and Ryuichi Morishita and Kensuke Egashira and Mitsuaki Isobe",
year = "2004",
month = "3",
day = "1",
doi = "10.1253/circj.68.270",
language = "English",
volume = "68",
pages = "270--271",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "3",

}

TY - JOUR

T1 - Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

AU - Suzuki, Jun Ichi

AU - Ito, Hiroshi

AU - Gotoh, Ryo

AU - Morishita, Ryuichi

AU - Egashira, Kensuke

AU - Isobe, Mitsuaki

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Background: Nuclear factor-κB (NF-κB) plays a pivotal role in restenosis after percutaneous coronary intervention (PCI) and the aim of the present clinical trials was to evaluate the effectiveness of a NF-κB decoy for preventing restenosis. Methods and Results: The initial case was a patient suffering from effort angina who had stenoses in the proximal and middle portions of the right coronary artery. The patient received 2 stents; the NF-κB decoy was delivered to the distal site, but not the proximal site. Six months after the PCI, the NF-κB decoy had suppressed restenosis in comparison with the no-decoy transfection site. The second case was a patient who underwent single-stent insertion and decoy transfection at the same site, and minimal intimal thickening was observed at 6 month after PCI. No systemic adverse effects were observed in either case. Conclusion: These results indicate the clinical usefulness and safety of NF-κB decoy transfection after PCI, but further evaluations are necessary to confirm its clinical effectiveness.

AB - Background: Nuclear factor-κB (NF-κB) plays a pivotal role in restenosis after percutaneous coronary intervention (PCI) and the aim of the present clinical trials was to evaluate the effectiveness of a NF-κB decoy for preventing restenosis. Methods and Results: The initial case was a patient suffering from effort angina who had stenoses in the proximal and middle portions of the right coronary artery. The patient received 2 stents; the NF-κB decoy was delivered to the distal site, but not the proximal site. Six months after the PCI, the NF-κB decoy had suppressed restenosis in comparison with the no-decoy transfection site. The second case was a patient who underwent single-stent insertion and decoy transfection at the same site, and minimal intimal thickening was observed at 6 month after PCI. No systemic adverse effects were observed in either case. Conclusion: These results indicate the clinical usefulness and safety of NF-κB decoy transfection after PCI, but further evaluations are necessary to confirm its clinical effectiveness.

UR - http://www.scopus.com/inward/record.url?scp=1642545592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642545592&partnerID=8YFLogxK

U2 - 10.1253/circj.68.270

DO - 10.1253/circj.68.270

M3 - Article

C2 - 14993786

AN - SCOPUS:1642545592

VL - 68

SP - 270

EP - 271

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 3

ER -