Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery

Kei Ichiro Takase, Hiroyuki Murai, Rina Tasaki, Shin Ichiro Miyahara, Shuji Kaneto, Mieko Shibata, Nobuyoshi Takashima

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Abstract

Background/Aims: The mechanisms underlying neurological deterioration in patients with acute lacunar infarction in the lenticulostriate artery (LSA) territory are currently unclear. We aimed to identify predictors for progressive neurological deficits using diffusion-weighted imaging (DWI). Methods: We studied 40 consecutive patients who were classified into two groups based on their NIHSS scores: progressive infarction (PI) and non-progressive infarction (NPI). We calculated the size of DWI abnormalities and evaluated clinical characteristics on admission for both groups. Results: 19 patients (47.5%) exhibited neurological deterioration. Time from onset to MRI was 8.2 ± 6.7 h for all patients. DWI area was significantly larger in the PI relative to the NPI group (1.1 ± 0.5 cm2 for PI vs. 0.7 ± 0.3 cm2 for NPI; p = 0.002), although patients' NIHSS scores at admission were not significantly different between both groups. The optimal cut-off value of infarct area between PI and NPI was 0.98 cm2. Multivariate analysis revealed that an infarct area on DWI ≥0.98 cm2 (odds ratio 10.57; 95% confidence interval 2.24-68.32; p = 0.006) was a significant independent predictor of PI. Conclusions: A large infarct area on initial DWI was an independent predictor of neurological deterioration in patients with acute lacunar infarctions in the LSA territory.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalEuropean Neurology
Volume65
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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Lacunar Stroke
Infarction
Arteries
Multivariate Analysis
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology

Cite this

Takase, K. I., Murai, H., Tasaki, R., Miyahara, S. I., Kaneto, S., Shibata, M., & Takashima, N. (2011). Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery. European Neurology, 65(6), 355-360. https://doi.org/10.1159/000327980

Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery. / Takase, Kei Ichiro; Murai, Hiroyuki; Tasaki, Rina; Miyahara, Shin Ichiro; Kaneto, Shuji; Shibata, Mieko; Takashima, Nobuyoshi.

In: European Neurology, Vol. 65, No. 6, 06.2011, p. 355-360.

Research output: Contribution to journalArticle

Takase, KI, Murai, H, Tasaki, R, Miyahara, SI, Kaneto, S, Shibata, M & Takashima, N 2011, 'Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery', European Neurology, vol. 65, no. 6, pp. 355-360. https://doi.org/10.1159/000327980
Takase, Kei Ichiro ; Murai, Hiroyuki ; Tasaki, Rina ; Miyahara, Shin Ichiro ; Kaneto, Shuji ; Shibata, Mieko ; Takashima, Nobuyoshi. / Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery. In: European Neurology. 2011 ; Vol. 65, No. 6. pp. 355-360.
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