Innate memory phenotype CD4 + T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner

Kenji Umeda, Xun Sun, Ying Guo, Hisakata Yamada, Kensuke Shibata, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    CD30 ligand (CD30L, CD153) is a type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. It is shown here that CD30L knock out (KO) mice are highly susceptible to primary infection with Listeria monocytogenes as assessed by the survival rate. There were significantly more bacteria on day 3 after infection in the peritoneal cavity, spleen and liver of CD30LKO mice than in wild type (WT) mice. The innate function of memory phenotype (MP) CD44 + CD4 + T cells for interferon-gamma production was significantly lower in CD30LKO mice than in WT mice in response to interleukin (IL)-12 and IL-15 in vitro. Depletion of CD4 + T cells by in vivo administration of anti-CD4 mAb at an early stage after infection hampered protection against Listeria. Furthermore, in vivo administration of agonistic anti-CD30 mAb restored protection against Listeria in CD30LKO mice, whereas treatment with soluble mCD30-Ig hampered protection in WT mice. Taken together, it appears that CD30L/CD30 signaling plays an important role in innate MPCD4 + T cell-mediated protection against infection with L. monocytogenes.

    Original languageEnglish
    Pages (from-to)645-656
    Number of pages12
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume55
    Issue number9
    DOIs
    Publication statusPublished - Sep 1 2011

    Fingerprint

    Listeria monocytogenes
    T-Lymphocytes
    Phenotype
    Infection
    Listeria
    CD30 Ligand
    Interleukin-15
    Cytoprotection
    Membrane Glycoproteins
    Peritoneal Cavity
    Interleukin-12
    Knockout Mice
    Interferon-gamma
    Spleen
    Tumor Necrosis Factor-alpha
    Bacteria
    Liver

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Virology

    Cite this

    Innate memory phenotype CD4 + T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner. / Umeda, Kenji; Sun, Xun; Guo, Ying; Yamada, Hisakata; Shibata, Kensuke; Yoshikai, Yasunobu.

    In: MICROBIOLOGY and IMMUNOLOGY, Vol. 55, No. 9, 01.09.2011, p. 645-656.

    Research output: Contribution to journalArticle

    Umeda, Kenji ; Sun, Xun ; Guo, Ying ; Yamada, Hisakata ; Shibata, Kensuke ; Yoshikai, Yasunobu. / Innate memory phenotype CD4 + T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner. In: MICROBIOLOGY and IMMUNOLOGY. 2011 ; Vol. 55, No. 9. pp. 645-656.
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