Innate versus learned odour processing in the mouse olfactory bulb

Ko Kobayakawa, Reiko Kobayakawa, Hideyuki Matsumoto, Yuichiro Oka, Takeshi Imai, Masahito Ikawa, Masaru Okabe, Toshio Ikeda, Shigeyoshi Itohara, Takefumi Kikusui, Kensaku Mori, Hitoshi Sakano

Research output: Contribution to journalArticle

385 Citations (Scopus)

Abstract

The mammalian olfactory system mediates various responses, including aversive behaviours to spoiled foods and fear responses to predator odours. In the olfactory bulb, each glomerulus represents a single species of odorant receptor. Because a single odorant can interact with several different receptor species, the odour information received in the olfactory epithelium is converted to a topographical map of multiple glomeruli activated in distinct areas in the olfactory bulb. To study how the odour map is interpreted in the brain, we generated mutant mice in which olfactory sensory neurons in a specific area of the olfactory epithelium are ablated by targeted expression of the diphtheria toxin gene. Here we show that, in dorsal-zone-depleted mice, the dorsal domain of the olfactory bulb was devoid of glomerular structures, although second-order neurons were present in the vacant areas. The mutant mice lacked innate responses to aversive odorants, even though they were capable of detecting them and could be conditioned for aversion with the remaining glomeruli. These results indicate that, in mice, aversive information is received in the olfactory bulb by separate sets of glomeruli, those dedicated for innate and those for learned responses.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalNature
Volume450
Issue number7169
DOIs
Publication statusPublished - Nov 21 2007
Externally publishedYes

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Olfactory Bulb
Olfactory Mucosa
Odorant Receptors
Olfactory Receptor Neurons
Diphtheria Toxin
Fear
Odorants
Neurons
Food
Brain
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., ... Sakano, H. (2007). Innate versus learned odour processing in the mouse olfactory bulb. Nature, 450(7169), 503-508. https://doi.org/10.1038/nature06281

Innate versus learned odour processing in the mouse olfactory bulb. / Kobayakawa, Ko; Kobayakawa, Reiko; Matsumoto, Hideyuki; Oka, Yuichiro; Imai, Takeshi; Ikawa, Masahito; Okabe, Masaru; Ikeda, Toshio; Itohara, Shigeyoshi; Kikusui, Takefumi; Mori, Kensaku; Sakano, Hitoshi.

In: Nature, Vol. 450, No. 7169, 21.11.2007, p. 503-508.

Research output: Contribution to journalArticle

Kobayakawa, K, Kobayakawa, R, Matsumoto, H, Oka, Y, Imai, T, Ikawa, M, Okabe, M, Ikeda, T, Itohara, S, Kikusui, T, Mori, K & Sakano, H 2007, 'Innate versus learned odour processing in the mouse olfactory bulb', Nature, vol. 450, no. 7169, pp. 503-508. https://doi.org/10.1038/nature06281
Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M et al. Innate versus learned odour processing in the mouse olfactory bulb. Nature. 2007 Nov 21;450(7169):503-508. https://doi.org/10.1038/nature06281
Kobayakawa, Ko ; Kobayakawa, Reiko ; Matsumoto, Hideyuki ; Oka, Yuichiro ; Imai, Takeshi ; Ikawa, Masahito ; Okabe, Masaru ; Ikeda, Toshio ; Itohara, Shigeyoshi ; Kikusui, Takefumi ; Mori, Kensaku ; Sakano, Hitoshi. / Innate versus learned odour processing in the mouse olfactory bulb. In: Nature. 2007 ; Vol. 450, No. 7169. pp. 503-508.
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