Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol

T. Kiguchi, Y. Tsurusaki, S. Yamada, M. Aso, M. Tanaka, K. Sakai, H. Suemune

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.

Original languageEnglish
Pages (from-to)1536-1540
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number10
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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