Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.
|Number of pages||5|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 2000|
All Science Journal Classification (ASJC) codes
- Drug Discovery