Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

Tomoko Kuwabara, Mohamedi N. Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H. Gage, Makoto Asashima

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes. See accompanying article http://dx.doi.org/10.1002/emmm.201100178

Original languageEnglish
Pages (from-to)742-754
Number of pages13
JournalEMBO Molecular Medicine
Volume3
Issue number12
DOIs
Publication statusPublished - Dec 1 2011

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Olfactory Bulb
Hippocampus
Insulin
Pancreas
Insulin-Like Growth Factor Binding Protein 4
Adult Stem Cells
Neural Stem Cells
Glucose
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

Cite this

Kuwabara, T., Kagalwala, M. N., Onuma, Y., Ito, Y., Warashina, M., Terashima, K., ... Asashima, M. (2011). Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Molecular Medicine, 3(12), 742-754. https://doi.org/10.1002/emmm.201100177

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. / Kuwabara, Tomoko; Kagalwala, Mohamedi N.; Onuma, Yasuko; Ito, Yuzuru; Warashina, Masaki; Terashima, Kazuyuki; Sanosaka, Tsukasa; Nakashima, Kinichi; Gage, Fred H.; Asashima, Makoto.

In: EMBO Molecular Medicine, Vol. 3, No. 12, 01.12.2011, p. 742-754.

Research output: Contribution to journalArticle

Kuwabara, T, Kagalwala, MN, Onuma, Y, Ito, Y, Warashina, M, Terashima, K, Sanosaka, T, Nakashima, K, Gage, FH & Asashima, M 2011, 'Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb', EMBO Molecular Medicine, vol. 3, no. 12, pp. 742-754. https://doi.org/10.1002/emmm.201100177
Kuwabara, Tomoko ; Kagalwala, Mohamedi N. ; Onuma, Yasuko ; Ito, Yuzuru ; Warashina, Masaki ; Terashima, Kazuyuki ; Sanosaka, Tsukasa ; Nakashima, Kinichi ; Gage, Fred H. ; Asashima, Makoto. / Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. In: EMBO Molecular Medicine. 2011 ; Vol. 3, No. 12. pp. 742-754.
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