Insulin effect on bupivacaine-induced cardiotoxicity in rabbits

Yun Suk Choi, Kook Hyun Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalKorean Journal of Anesthesiology
Volume61
Issue number6
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

Bupivacaine
Insulin
Rabbits
Control Groups
Pentobarbital
Resuscitation
Cardiotoxicity
Heart Rate
Injections

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Insulin effect on bupivacaine-induced cardiotoxicity in rabbits. / Choi, Yun Suk; Lee, Kook Hyun.

In: Korean Journal of Anesthesiology, Vol. 61, No. 6, 01.01.2011, p. 493-498.

Research output: Contribution to journalArticle

Choi, Yun Suk ; Lee, Kook Hyun. / Insulin effect on bupivacaine-induced cardiotoxicity in rabbits. In: Korean Journal of Anesthesiology. 2011 ; Vol. 61, No. 6. pp. 493-498.
@article{23358b397fb1475ea2e0fb852207068d,
title = "Insulin effect on bupivacaine-induced cardiotoxicity in rabbits",
abstract = "Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9{\%} NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.",
author = "Choi, {Yun Suk} and Lee, {Kook Hyun}",
year = "2011",
month = "1",
day = "1",
doi = "10.4097/kjae.2011.61.6.493",
language = "English",
volume = "61",
pages = "493--498",
journal = "Korean Journal of Anesthesiology",
issn = "2005-6419",
publisher = "Korean Society of Anesthesiologists",
number = "6",

}

TY - JOUR

T1 - Insulin effect on bupivacaine-induced cardiotoxicity in rabbits

AU - Choi, Yun Suk

AU - Lee, Kook Hyun

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.

AB - Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.

UR - http://www.scopus.com/inward/record.url?scp=84855324120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855324120&partnerID=8YFLogxK

U2 - 10.4097/kjae.2011.61.6.493

DO - 10.4097/kjae.2011.61.6.493

M3 - Article

AN - SCOPUS:84855324120

VL - 61

SP - 493

EP - 498

JO - Korean Journal of Anesthesiology

JF - Korean Journal of Anesthesiology

SN - 2005-6419

IS - 6

ER -