Abstract
Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.
| Original language | English |
|---|---|
| Pages (from-to) | 493-498 |
| Number of pages | 6 |
| Journal | Korean Journal of Anesthesiology |
| Volume | 61 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jan 1 2011 |
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All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine
Cite this
Insulin effect on bupivacaine-induced cardiotoxicity in rabbits. / Choi, Yun Suk; Lee, Kook Hyun.
In: Korean Journal of Anesthesiology, Vol. 61, No. 6, 01.01.2011, p. 493-498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin effect on bupivacaine-induced cardiotoxicity in rabbits
AU - Choi, Yun Suk
AU - Lee, Kook Hyun
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.
AB - Background: Resuscitation following bupivacaine-induced cardiovascular collapse is difficult and often refractoryto conventional treatment. This study was performed to assess the effect of insulin on bupivacaine-inducedcardiovascular collapse in pentobarbital-anesthetized rabbits.Methods: Bupivacaine was administered at 0.75 mg/kg/min until the heart rate decreased to 65 beats/min. A bolusof regular insulin (2 U/kg) was administered intravenously at the bupivacaine infusion endpoint (BIE) in the insulingroup (n = 8), and 2 mL of 0.9% NaCl was administered to the control group (n = 8).Results: All animals in the insulin group survived and four animals died in the control group. Arrythymia was rare 10minutes after the BIE in the insulin group.Conclusions: Bupivacaine-induced cardiovascular collapse can be effectively reversed with an insulin injection,probably through facilitation of cardiac conduction and contraction.
UR - http://www.scopus.com/inward/record.url?scp=84855324120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855324120&partnerID=8YFLogxK
U2 - 10.4097/kjae.2011.61.6.493
DO - 10.4097/kjae.2011.61.6.493
M3 - Article
AN - SCOPUS:84855324120
VL - 61
SP - 493
EP - 498
JO - Korean Journal of Anesthesiology
JF - Korean Journal of Anesthesiology
SN - 2005-6419
IS - 6
ER -