Abstract
Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30min and plasma bupivacaine concentrations at every 5min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
| Original language | English |
|---|---|
| Article number | 878764 |
| Journal | Anesthesiology Research and Practice |
| Volume | 2012 |
| DOIs | |
| Publication status | Published - May 21 2012 |
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All Science Journal Classification (ASJC) codes
- Critical Care and Intensive Care Medicine
- Anesthesiology and Pain Medicine
Cite this
Insulin facilitates the recovery of myocardial contractility and conduction during cardiac compression in rabbits with bupivacaine-induced cardiovascular collapse. / Yang, Solmon; Uugangerel, Tserendorj; Jang, In Ki; Lee, Hyung Chul; Kim, Jong Min; Kang, Byeong Cheol; Kim, Chong Soo; Lee, Kook Hyun.
In: Anesthesiology Research and Practice, Vol. 2012, 878764, 21.05.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin facilitates the recovery of myocardial contractility and conduction during cardiac compression in rabbits with bupivacaine-induced cardiovascular collapse
AU - Yang, Solmon
AU - Uugangerel, Tserendorj
AU - Jang, In Ki
AU - Lee, Hyung Chul
AU - Kim, Jong Min
AU - Kang, Byeong Cheol
AU - Kim, Chong Soo
AU - Lee, Kook Hyun
PY - 2012/5/21
Y1 - 2012/5/21
N2 - Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30min and plasma bupivacaine concentrations at every 5min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
AB - Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30min and plasma bupivacaine concentrations at every 5min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
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U2 - 10.1155/2012/878764
DO - 10.1155/2012/878764
M3 - Article
VL - 2012
JO - Anesthesiology Research and Practice
JF - Anesthesiology Research and Practice
SN - 1687-6962
M1 - 878764
ER -