Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast

Katsumi Takizawa, Hidetaka Yamamoto, Kenichi Taguchi, Shinji Ohno, Eriko Tokunaga, Nami Yamashita, Makoto Kubo, Masafumi Nakamura, Yoshinao Oda

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3 Citations (Scopus)

Abstract

The aim of this study was to elucidate the clinicopathological and prognostic significance of the expressions of insulin-like growth factor II mRNA-binding protein-3 (IMP3) and epidermal growth factor receptor (EGFR) in phyllodes tumors (PTs). Immunohistochemical staining for IMP3 and EGFR was performed in 130 cases of primary PTs (83 benign, 28 borderline, 19 malignant), 34 recurrent/metastatic PTs, and 26 fibroadenomas (FAs). Among the primary tumors, a high expression of IMP3 was significantly more frequently present in malignant PTs (17/19, 89%) than in the FAs (0/26, 0%), benign PTs (0/83, 0%) and borderline PTs (3/28, 11%). The recurrent and metastatic lesions of malignant PTs also showed high IMP3 expression (3/5 [60%] and 6/6 [100%], respectively). Most malignant PTs showed strong IMP3 expression at the interductal area or more diffusely, whereas weak and focal (low) expression of IMP3 was limited to the periductal area in FAs and benign PTs. EGFR overexpression was significantly correlated with tumor grade and high IMP3 expression. Overexpressions of IMP3 and EGFR were significantly associated with shorter periods of metastasis-free and disease-free survival. The results suggest that high expressions of IMP3 and EGFR with a characteristic staining pattern may be helpful for both identifying malignant PT and predicting the prognosis of these tumors.

Original languageEnglish
Pages (from-to)30-38
Number of pages9
JournalHuman Pathology
Volume55
DOIs
Publication statusPublished - Sep 1 2016

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Phyllodes Tumor
Insulin-Like Growth Factor II
RNA-Binding Proteins
Carrier Proteins
Breast Neoplasms
Messenger RNA
Epidermal Growth Factor Receptor
Fibroadenoma
Staining and Labeling
Neoplasms
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast. / Takizawa, Katsumi; Yamamoto, Hidetaka; Taguchi, Kenichi; Ohno, Shinji; Tokunaga, Eriko; Yamashita, Nami; Kubo, Makoto; Nakamura, Masafumi; Oda, Yoshinao.

In: Human Pathology, Vol. 55, 01.09.2016, p. 30-38.

Research output: Contribution to journalArticle

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AU - Ohno, Shinji

AU - Tokunaga, Eriko

AU - Yamashita, Nami

AU - Kubo, Makoto

AU - Nakamura, Masafumi

AU - Oda, Yoshinao

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