Insulin resistance is a risk factor for increased intraocular pressure: The Hisayama study

Kohta Fujiwara, Miho Yasuda, Toshiharu Ninomiya, Jun Hata, Sawako Hashimoto, Takeshi Yoshitomi, Yutaka Kiyohara, Tatsuro Ishibashi

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population. METHODS. In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP. RESULTS. The mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08). CONCLUSIONS. The HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.

Original languageEnglish
Pages (from-to)7983-7987
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number13
DOIs
Publication statusPublished - Dec 1 2015

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Intraocular Pressure
Insulin Resistance
Homeostasis
Linear Models
Blood Pressure
Waist Circumference
HDL Cholesterol
Habits
Fasting
Body Mass Index
Smoking
Cholesterol
Alcohols
Exercise
Insulin
Glucose
Serum
Population

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Insulin resistance is a risk factor for increased intraocular pressure : The Hisayama study. / Fujiwara, Kohta; Yasuda, Miho; Ninomiya, Toshiharu; Hata, Jun; Hashimoto, Sawako; Yoshitomi, Takeshi; Kiyohara, Yutaka; Ishibashi, Tatsuro.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 13, 01.12.2015, p. 7983-7987.

Research output: Contribution to journalArticle

Fujiwara, Kohta ; Yasuda, Miho ; Ninomiya, Toshiharu ; Hata, Jun ; Hashimoto, Sawako ; Yoshitomi, Takeshi ; Kiyohara, Yutaka ; Ishibashi, Tatsuro. / Insulin resistance is a risk factor for increased intraocular pressure : The Hisayama study. In: Investigative Ophthalmology and Visual Science. 2015 ; Vol. 56, No. 13. pp. 7983-7987.
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