Integrated comprehensive workbench for systems biology: Inference of genetic interaction and systems analysis of metabolic pathways

Masahiko Nakatsui, Yukihiro Maki, Tatsuya Sekiguchi, Masahiro Okamoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose integrated, comprehensive workbenches for systems identification and for systems analysis in systems biology. The former is named VoyaGene, which can analyze experimentally observed expression profiles by using and combining the five independent inferring models: clustering, threshold-test, Bayesian, multi-level digraph and S-system models. The latter is named WinBEST-KIT, which allow users to define original mathematical equations and to customize these equations very easily as user-defined reaction symbols. The following powerful system-analytical methods are prepared for systems analysis: time-course calculation, parameter scanning, estimation of the values of unknown kinetic parameters based on experimentally observed time-course data of reactants, dynamic response of reactants against virtual external perturbations and real-time simulation (virtual dry lab).

Original languageEnglish
Title of host publicationWMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.
Pages7-12
Number of pages6
Publication statusPublished - Dec 1 2007
Event11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Orlando, FL, United States
Duration: Jul 8 2007Jul 11 2007

Publication series

NameWMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.
Volume4

Other

Other11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007
CountryUnited States
CityOrlando, FL
Period7/8/077/11/07

Fingerprint

Systems analysis
Kinetic parameters
Dynamic response
Identification (control systems)
Scanning
Systems Biology
Metabolic Networks and Pathways

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Information Systems

Cite this

Nakatsui, M., Maki, Y., Sekiguchi, T., & Okamoto, M. (2007). Integrated comprehensive workbench for systems biology: Inference of genetic interaction and systems analysis of metabolic pathways. In WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc. (pp. 7-12). (WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.; Vol. 4).

Integrated comprehensive workbench for systems biology : Inference of genetic interaction and systems analysis of metabolic pathways. / Nakatsui, Masahiko; Maki, Yukihiro; Sekiguchi, Tatsuya; Okamoto, Masahiro.

WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. 2007. p. 7-12 (WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.; Vol. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nakatsui, M, Maki, Y, Sekiguchi, T & Okamoto, M 2007, Integrated comprehensive workbench for systems biology: Inference of genetic interaction and systems analysis of metabolic pathways. in WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc., vol. 4, pp. 7-12, 11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007, Orlando, FL, United States, 7/8/07.
Nakatsui M, Maki Y, Sekiguchi T, Okamoto M. Integrated comprehensive workbench for systems biology: Inference of genetic interaction and systems analysis of metabolic pathways. In WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. 2007. p. 7-12. (WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.).
Nakatsui, Masahiko ; Maki, Yukihiro ; Sekiguchi, Tatsuya ; Okamoto, Masahiro. / Integrated comprehensive workbench for systems biology : Inference of genetic interaction and systems analysis of metabolic pathways. WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. 2007. pp. 7-12 (WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.).
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