Integrated endoscopic system based on optical imaging and hyperspectral data analysis for colorectal cancer detection

Ryuichi Kumashiro, Kozo Konishi, Tohru Chiba, Tomohiko Akahoshi, Shotaro Nakamura, Masaharu Murata, Morimasa Tomikawa, Takayuki Matsumoto, Yoshihiko Maehara, Makoto Hashizume

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13 Citations (Scopus)

Abstract

Background/Aim: Two-dimensional hyperspectral data systems with enhanced area detection and diagnostic abilities are now available in gastrointestinal endoscopy for colorectal cancer. We evaluated a new hyperspectral system for diagnosis of colorectal cancer. Patients and Methods: A resected-specimen spectrum observation module (stereoscopic macroscope, hyperspectral camera, and xenon lamp) was used to evaluate 21 resected colorectal cancer specimens (ex vivo experiment). A colonoscopy spectrum observation module (imaging fiberscope and hyperspectral camera) was used to perform 24 colonoscopic spectroscopy evaluations (in vivo experiment). Results: An approximately 525-nm increase in spectral absorption occurred between normal mucosa and adenoma, with a tendency toward decreased absorption rates with aggravation of other tumor types. In vivo discrimination between tumorous and non-tumorous tissues showed 72.5% sensitivity and 82.1% specificity. Conclusion: This in vivo hyperspectral diagnostic system showed that reflectance spectra intensity may discriminate between normal and abnormal colonic mucosa.

Original languageEnglish
Pages (from-to)3925-3932
Number of pages8
JournalAnticancer research
Volume36
Issue number8
Publication statusPublished - Aug 2016

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kumashiro, R., Konishi, K., Chiba, T., Akahoshi, T., Nakamura, S., Murata, M., ... Hashizume, M. (2016). Integrated endoscopic system based on optical imaging and hyperspectral data analysis for colorectal cancer detection. Anticancer research, 36(8), 3925-3932.