Integrated network systems and evolutionary developmental endocrinology

Hiroyuki Koshiyama, Yoshihiro Ogawa, Kiyoshi Tanaka, Issei Tanaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Endocrine system has been considered to be a linear one, but the 'real world endocrine system' is a complex system, which is difficult to investigate using conventional strategies, such as single nucleotide polymorphism, genome-wide analysis, or gene targeting in animals. Here we propose a new strategy to comprehend the endocrine system as a complex network system. We introduced several novel concepts, such as complex system, network analysis, systems biology and evolutionary medicine, into the comprehension of endocrine system as a whole complex network system. This system is considered to be a scale-free network with key molecules such as acetyl CoA, NAD or ATP as 'hubs'. This system is robust against simple mutations, but various complex diseases may attack hubs. The system is also 'fractals', since there exist similar network systems among cells, proteins, and transcription factors in the lower levels, and there are similar ones among disease and social network in the higher levels. We propose to call this model 'Integrated Network Systems and Evolutionary DEvelopmental ENdocrinology (INS-EDEN)'. This novel framework will facilitate us to develop a new approach for understanding and treatment of various complex diseases related to endocrinology, and identify a unified theory of complex diseases.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalMedical Hypotheses
Volume74
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

Fingerprint

Endocrine System
Endocrinology
Fractals
Acetyl Coenzyme A
Systems Biology
Gene Targeting
Social Support
NAD
Single Nucleotide Polymorphism
Transcription Factors
Medicine
Genome
Mutation
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Integrated network systems and evolutionary developmental endocrinology. / Koshiyama, Hiroyuki; Ogawa, Yoshihiro; Tanaka, Kiyoshi; Tanaka, Issei.

In: Medical Hypotheses, Vol. 74, No. 1, 01.01.2010, p. 132-138.

Research output: Contribution to journalArticle

Koshiyama, Hiroyuki ; Ogawa, Yoshihiro ; Tanaka, Kiyoshi ; Tanaka, Issei. / Integrated network systems and evolutionary developmental endocrinology. In: Medical Hypotheses. 2010 ; Vol. 74, No. 1. pp. 132-138.
@article{22ed70fefde64e79bc6c190fea0b7822,
title = "Integrated network systems and evolutionary developmental endocrinology",
abstract = "Endocrine system has been considered to be a linear one, but the 'real world endocrine system' is a complex system, which is difficult to investigate using conventional strategies, such as single nucleotide polymorphism, genome-wide analysis, or gene targeting in animals. Here we propose a new strategy to comprehend the endocrine system as a complex network system. We introduced several novel concepts, such as complex system, network analysis, systems biology and evolutionary medicine, into the comprehension of endocrine system as a whole complex network system. This system is considered to be a scale-free network with key molecules such as acetyl CoA, NAD or ATP as 'hubs'. This system is robust against simple mutations, but various complex diseases may attack hubs. The system is also 'fractals', since there exist similar network systems among cells, proteins, and transcription factors in the lower levels, and there are similar ones among disease and social network in the higher levels. We propose to call this model 'Integrated Network Systems and Evolutionary DEvelopmental ENdocrinology (INS-EDEN)'. This novel framework will facilitate us to develop a new approach for understanding and treatment of various complex diseases related to endocrinology, and identify a unified theory of complex diseases.",
author = "Hiroyuki Koshiyama and Yoshihiro Ogawa and Kiyoshi Tanaka and Issei Tanaka",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/j.mehy.2009.07.028",
language = "English",
volume = "74",
pages = "132--138",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - Integrated network systems and evolutionary developmental endocrinology

AU - Koshiyama, Hiroyuki

AU - Ogawa, Yoshihiro

AU - Tanaka, Kiyoshi

AU - Tanaka, Issei

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Endocrine system has been considered to be a linear one, but the 'real world endocrine system' is a complex system, which is difficult to investigate using conventional strategies, such as single nucleotide polymorphism, genome-wide analysis, or gene targeting in animals. Here we propose a new strategy to comprehend the endocrine system as a complex network system. We introduced several novel concepts, such as complex system, network analysis, systems biology and evolutionary medicine, into the comprehension of endocrine system as a whole complex network system. This system is considered to be a scale-free network with key molecules such as acetyl CoA, NAD or ATP as 'hubs'. This system is robust against simple mutations, but various complex diseases may attack hubs. The system is also 'fractals', since there exist similar network systems among cells, proteins, and transcription factors in the lower levels, and there are similar ones among disease and social network in the higher levels. We propose to call this model 'Integrated Network Systems and Evolutionary DEvelopmental ENdocrinology (INS-EDEN)'. This novel framework will facilitate us to develop a new approach for understanding and treatment of various complex diseases related to endocrinology, and identify a unified theory of complex diseases.

AB - Endocrine system has been considered to be a linear one, but the 'real world endocrine system' is a complex system, which is difficult to investigate using conventional strategies, such as single nucleotide polymorphism, genome-wide analysis, or gene targeting in animals. Here we propose a new strategy to comprehend the endocrine system as a complex network system. We introduced several novel concepts, such as complex system, network analysis, systems biology and evolutionary medicine, into the comprehension of endocrine system as a whole complex network system. This system is considered to be a scale-free network with key molecules such as acetyl CoA, NAD or ATP as 'hubs'. This system is robust against simple mutations, but various complex diseases may attack hubs. The system is also 'fractals', since there exist similar network systems among cells, proteins, and transcription factors in the lower levels, and there are similar ones among disease and social network in the higher levels. We propose to call this model 'Integrated Network Systems and Evolutionary DEvelopmental ENdocrinology (INS-EDEN)'. This novel framework will facilitate us to develop a new approach for understanding and treatment of various complex diseases related to endocrinology, and identify a unified theory of complex diseases.

UR - http://www.scopus.com/inward/record.url?scp=70450228506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70450228506&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2009.07.028

DO - 10.1016/j.mehy.2009.07.028

M3 - Article

C2 - 19674847

AN - SCOPUS:70450228506

VL - 74

SP - 132

EP - 138

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 1

ER -