TY - JOUR
T1 - Interaction between epidermal growth factor and triamcinolone acetonide in mouse palatal mesenchymal cells in vitro
AU - Kukita, T.
AU - Kurisu, K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - Palatal mesenchymal cells from mouse embryos (MEPM cells) had a high number of specific receptors for epidermal growth factor (EGF). At 37 °C, the number of high-affinity receptors (dissociation constant, Kd of 6.0 × 10-10 M) was 2.0 × 105 per cell and of low-affinity receptors (Kd of 2.9 × 10-9 M), 3.8 × 105 per cell. At 2 °C, a single class of receptors (Kd of 4.8 × 10-9 M) was detected at 1.8 × 105 per cell. Triamcinolone acetonide, a potent cleft-palate-inducing agent, slightly inhibited the recovery of 125I-labelled EGF binding capacity in MEPM cells after down regulation of EGF receptors; it did not affect the binding properties of 125I-labelled EGF in these cells.
AB - Palatal mesenchymal cells from mouse embryos (MEPM cells) had a high number of specific receptors for epidermal growth factor (EGF). At 37 °C, the number of high-affinity receptors (dissociation constant, Kd of 6.0 × 10-10 M) was 2.0 × 105 per cell and of low-affinity receptors (Kd of 2.9 × 10-9 M), 3.8 × 105 per cell. At 2 °C, a single class of receptors (Kd of 4.8 × 10-9 M) was detected at 1.8 × 105 per cell. Triamcinolone acetonide, a potent cleft-palate-inducing agent, slightly inhibited the recovery of 125I-labelled EGF binding capacity in MEPM cells after down regulation of EGF receptors; it did not affect the binding properties of 125I-labelled EGF in these cells.
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U2 - 10.1016/0003-9969(86)90111-1
DO - 10.1016/0003-9969(86)90111-1
M3 - Article
C2 - 3010916
AN - SCOPUS:0022565507
SN - 0003-9969
VL - 31
SP - 39
EP - 44
JO - Archives of Oral Biology
JF - Archives of Oral Biology
IS - 1
ER -