The pathogenesis of Alzheimer's disease is known to be related to the glycosaminoglycans that are associated with the deposition of amyloid beta (Aβ) peptides. We prepared heparin-mimicking multimeric saccharides and investigated their interactions with Aβ peptides in solution. The results showed that multimeric saccharides, especially the dimeric saccharide, strongly inhibited β-sheeted Aβ aggregation as assessed by the thioflavin-T (Th-T) assay, average zeta potential measurements and atomic force microscopy (AFM). This result suggested that the amyloidosis of Aβ (1-42) was affected by the multivalency of saccharides even in the solution.
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