Interaction between multimeric sulfated saccharides and Alzheimer amyloid β (1-42)

Tomohiro Fukuda, Erino Matsumoto, Yoshiko Miura

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4 Citations (Scopus)

Abstract

The pathogenesis of Alzheimer's disease is known to be related to the glycosaminoglycans that are associated with the deposition of amyloid beta (Aβ) peptides. We prepared heparin-mimicking multimeric saccharides and investigated their interactions with Aβ peptides in solution. The results showed that multimeric saccharides, especially the dimeric saccharide, strongly inhibited β-sheeted Aβ aggregation as assessed by the thioflavin-T (Th-T) assay, average zeta potential measurements and atomic force microscopy (AFM). This result suggested that the amyloidosis of Aβ (1-42) was affected by the multivalency of saccharides even in the solution.

Original languageEnglish
Pages (from-to)1482-1484
Number of pages3
JournalChemistry Letters
Volume44
Issue number11
DOIs
Publication statusPublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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