Interaction between Viral Proteins and Mitochondria

Takuma Yoshizumi, Kai Yasukawa, Takumi Koshiba

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances reveal that mitochondria are not limited to functioning only as the cellular powerhouse and in apoptosis, but that they act as central hubs for multiple signal transductions. Studies over the last decade indicate that mitochondria in vertebrates are involved in the front line of host defense, especially against RNA viruses. Mitochondrial-mediated antiviral innate immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway, and the mitochondrial surface acts as a platform for the assembly of signaling molecules, including mitochondrial antiviral signaling (MAVS) during the process. Some viral encoded proteins target to the mitochondria post-infection, however, thereby evading the cellular immune response. Here we review specific interactions between mitochondria and viral proteins and discuss their physiologic effects on the host cells.

Original languageEnglish
Pages (from-to)148-154
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume107
Issue number8
Publication statusPublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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