Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks

Rong Zhang, Tomonori Nakanishi, Atsushi Ohgushi, Ryuichi Ando, Takao Yoshimatsu, D. Michael Denbow, Mitsuhiro Furuse

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Abstract

Both corticortropin-releasing factor (CRF) and glucagon-like peptide-1 (GLP-1) inhibit food intake of chicks, but they also produce other behaviors. The present experiments were undertaken to clarify the interaction of CRF and GLP-1 regarding their anorectic actions as well as other behaviors. In Experiment 1, birds were injected intracerebroventricularly (i.c.v.), following a 3-h fast, with either saline, 0.1 μg of CRF, 0.1 μg of CRF + 0.1 μg of GLP-1 or 0.1 μg of CRF + 1 μg of GLP-1, and food intake was measured for 2 h. The injection of CRF decreased food intake, and CRF injected with GLP-1 suppressed food intake for up to 2 h. Birds were treated similarly in Experiment 2 in which the doses of CRF and GLP-1 were reversed. GLP-1 strongly suppressed food intake, and this effect was augmented by coadministration of CRF. In Experiment 3, the behaviors of chicks injected with saline, CRF (0.1 μg), GLP-1 (0.1 μg) or CRF (0.1 μg) + GLP-1 (0.1 μg) were monitored for the numbers of steps, vocalization and locomotion. Chicks were excited, moved more and vocalized loudly following injection of CRF, whereas an opposite response was seen with GLP-1. The behaviors were intermediate following the coinjection of the two peptides. In conclusion, CRF and GLP-1 interact in the chick brain, but the response depends on the behavior being measured.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalEuropean Journal of Pharmacology
Volume430
Issue number1
DOIs
Publication statusPublished - Oct 26 2001

Fingerprint

Glucagon-Like Peptide 1
Corticotropin-Releasing Hormone
Eating
Birds
Appetite Depressants
Injections
Locomotion

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks. / Zhang, Rong; Nakanishi, Tomonori; Ohgushi, Atsushi; Ando, Ryuichi; Yoshimatsu, Takao; Denbow, D. Michael; Furuse, Mitsuhiro.

In: European Journal of Pharmacology, Vol. 430, No. 1, 26.10.2001, p. 73-78.

Research output: Contribution to journalArticle

Zhang, Rong ; Nakanishi, Tomonori ; Ohgushi, Atsushi ; Ando, Ryuichi ; Yoshimatsu, Takao ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks. In: European Journal of Pharmacology. 2001 ; Vol. 430, No. 1. pp. 73-78.
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