Abstract
The suitability of synchrotron radiation circular dichroism spectroscopy (SRCD) for studying interactions between the tricyclic peptide inhibitor siamycin I and the intact FsrC membrane sensor kinase in detergent micelles has been established. In the present study, tertiary structural changes demonstrate that inhibitor binding occurs at a different, non-overlapping site to the native ligand, GBAP.
Original language | English |
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Pages (from-to) | 444-447 |
Number of pages | 4 |
Journal | Physical Chemistry Chemical Physics |
Volume | 15 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 14 2013 |
All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)
- Physical and Theoretical Chemistry