Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism

Mary K. Phillips-Jones, Simon G. Patching, Shalini Edara, Jiro Nakayama, Rohanah Hussain, Giuliano Siligardi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The suitability of synchrotron radiation circular dichroism spectroscopy (SRCD) for studying interactions between the tricyclic peptide inhibitor siamycin I and the intact FsrC membrane sensor kinase in detergent micelles has been established. In the present study, tertiary structural changes demonstrate that inhibitor binding occurs at a different, non-overlapping site to the native ligand, GBAP.

Original languageEnglish
Pages (from-to)444-447
Number of pages4
JournalPhysical Chemistry Chemical Physics
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 14 2013

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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