Abstract
Herein, we report a rare case of amelanotic spindle-cell melanoma on the interdigit of the left fifth toe of an 83-year-old woman. She also had tinea pedis on the same part for more than 2 years, and the part in which the tumor developed had been macerated and colonized with both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Histopathologically, the biopsy specimen was indistinguishable from that of nonspecific inflammatory granulation. Two biopsies could not lead us to the correct diagnosis until the totally excised specimen was evaluated with immunohistochemical analysis including S-100 and other melanocyte markers. The patient died with multiple metastases of the tumor 18 months after her first visit. This case suggests that refractory interdigital dermatophytoses should be treated by considering the possibility of concomitant malignant neoplasms, and immunohistochemical analysis is indispensable for differential diagnosis of malignant neoplasms suggesting nonspecific granulation.
| Original language | English |
|---|---|
| Pages (from-to) | 716-719 |
| Number of pages | 4 |
| Journal | Journal of Dermatology |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2007 |
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All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. / Dainichi, Teruki; Kobayashi, Chikashi; Fujita, Shohei; Shiramizu, Kei; Ishiko, Toshiyuki; Kiryu, Hiromaro; Urabe, Kazunori; Tsuneyoshi, Masazumi; Furue, Masutaka.
In: Journal of Dermatology, Vol. 34, No. 10, 01.10.2007, p. 716-719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis
AU - Dainichi, Teruki
AU - Kobayashi, Chikashi
AU - Fujita, Shohei
AU - Shiramizu, Kei
AU - Ishiko, Toshiyuki
AU - Kiryu, Hiromaro
AU - Urabe, Kazunori
AU - Tsuneyoshi, Masazumi
AU - Furue, Masutaka
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Herein, we report a rare case of amelanotic spindle-cell melanoma on the interdigit of the left fifth toe of an 83-year-old woman. She also had tinea pedis on the same part for more than 2 years, and the part in which the tumor developed had been macerated and colonized with both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Histopathologically, the biopsy specimen was indistinguishable from that of nonspecific inflammatory granulation. Two biopsies could not lead us to the correct diagnosis until the totally excised specimen was evaluated with immunohistochemical analysis including S-100 and other melanocyte markers. The patient died with multiple metastases of the tumor 18 months after her first visit. This case suggests that refractory interdigital dermatophytoses should be treated by considering the possibility of concomitant malignant neoplasms, and immunohistochemical analysis is indispensable for differential diagnosis of malignant neoplasms suggesting nonspecific granulation.
AB - Herein, we report a rare case of amelanotic spindle-cell melanoma on the interdigit of the left fifth toe of an 83-year-old woman. She also had tinea pedis on the same part for more than 2 years, and the part in which the tumor developed had been macerated and colonized with both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Histopathologically, the biopsy specimen was indistinguishable from that of nonspecific inflammatory granulation. Two biopsies could not lead us to the correct diagnosis until the totally excised specimen was evaluated with immunohistochemical analysis including S-100 and other melanocyte markers. The patient died with multiple metastases of the tumor 18 months after her first visit. This case suggests that refractory interdigital dermatophytoses should be treated by considering the possibility of concomitant malignant neoplasms, and immunohistochemical analysis is indispensable for differential diagnosis of malignant neoplasms suggesting nonspecific granulation.
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U2 - 10.1111/j.1346-8138.2007.00367.x
DO - 10.1111/j.1346-8138.2007.00367.x
M3 - Article
VL - 34
SP - 716
EP - 719
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 10
ER -