Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis

Teruki Dainichi, Chikashi Kobayashi, Shohei Fujita, Kei Shiramizu, Toshiyuki Ishiko, Hiromaro Kiryu, Kazunori Urabe, Masazumi Tsuneyoshi, Masutaka Furue

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Herein, we report a rare case of amelanotic spindle-cell melanoma on the interdigit of the left fifth toe of an 83-year-old woman. She also had tinea pedis on the same part for more than 2 years, and the part in which the tumor developed had been macerated and colonized with both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Histopathologically, the biopsy specimen was indistinguishable from that of nonspecific inflammatory granulation. Two biopsies could not lead us to the correct diagnosis until the totally excised specimen was evaluated with immunohistochemical analysis including S-100 and other melanocyte markers. The patient died with multiple metastases of the tumor 18 months after her first visit. This case suggests that refractory interdigital dermatophytoses should be treated by considering the possibility of concomitant malignant neoplasms, and immunohistochemical analysis is indispensable for differential diagnosis of malignant neoplasms suggesting nonspecific granulation.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalJournal of Dermatology
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 1 2007

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Tinea
Melanoma
Neoplasms
Tinea Pedis
Biopsy
Melanocytes
Toes
Methicillin-Resistant Staphylococcus aureus
Pseudomonas aeruginosa
Differential Diagnosis
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. / Dainichi, Teruki; Kobayashi, Chikashi; Fujita, Shohei; Shiramizu, Kei; Ishiko, Toshiyuki; Kiryu, Hiromaro; Urabe, Kazunori; Tsuneyoshi, Masazumi; Furue, Masutaka.

In: Journal of Dermatology, Vol. 34, No. 10, 01.10.2007, p. 716-719.

Research output: Contribution to journalArticle

Dainichi, T, Kobayashi, C, Fujita, S, Shiramizu, K, Ishiko, T, Kiryu, H, Urabe, K, Tsuneyoshi, M & Furue, M 2007, 'Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis', Journal of Dermatology, vol. 34, no. 10, pp. 716-719. https://doi.org/10.1111/j.1346-8138.2007.00367.x
Dainichi, Teruki ; Kobayashi, Chikashi ; Fujita, Shohei ; Shiramizu, Kei ; Ishiko, Toshiyuki ; Kiryu, Hiromaro ; Urabe, Kazunori ; Tsuneyoshi, Masazumi ; Furue, Masutaka. / Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. In: Journal of Dermatology. 2007 ; Vol. 34, No. 10. pp. 716-719.
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