Purpose: A patient with aggressive chronic active Epstein-Barr virus (CAEBV) infection is described whose disease activity subsided after interferon (IFN)-α therapy. Patient and Methods: The patient had intermittent fever, cytopenia, liver dysfunction, hepatosplenomegaly, abnormal titers of EBV-associated antibodies, and positive EBV genomes. Results: Despite repeated trials of the antiviral agents prednisolone and γ- globulin, his condition deteriorated. The administration of IFN-α (1 x 105 U/kg subcutaneously 3 times per week) led to a dramatic clinical improvement. During the IFN-α therapy, the rearrangement bands of T-cell antigen receptor genes disappeared assessed by Southern blotting with a decrease in the number of activated T cells, although the EBV-genome remained evident. Conclusions: These observations suggest that IFN-α is useful in managing CAEBV, possibly restraining the clonal development of T-lymphoproliferative disease (LPD) and EBV-associated B-LPD, although it does not eradicate the proliferation of EBV.
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health