Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2: A project of the Kyushu University Liver Diseases Study Group

Norihiro Furusyo, Masaki Katoh, Yuichi Tababe, Eiji Kajiwara, Toshihiro Maruyama, Junya Shimono, Hironori Sakai, Makoto Nakamuta, Hideyuki Nomura, Akihide Masumoto, Shinji Shimoda, Kazuhiro Takahashi, Koichi Azuma, Jun Hayashi, H. Nakashima, M. Murata, K. Toyoda, H. Takeoka, T. Kuga, A. MitsutakeR. Sugimoto, H. Amagase, S. Tominaga, K. Yanagita, K. Ogiwara, M. Tokumatsu, S. Tabata, M. Yokota, H. Tanaka, S. Nagase, S. Tsuruta, S. Tada, M. Nagano, M. Honda, T. Umeno, T. Sugimura, S. Ueno, K. Miki, H. Okubo, H. Fujimoto, N. Higuchi, S. Shigematsu, N. Higashi

Research output: Contribution to journalArticle

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Abstract

Aim: To determine the efficacy of an interferon alpha and ribavirin combination treatment for Japanese patients infected with hepatitis C virus (HCV) of genotype 2, a multi-center study was retrospectively analyzed. Methods: In total, 173 patients with HCV genotype 2 started to receive interferon-alpha subcutaneously thrice a week and 600-800 mg of ribavirin daily for 24 wk. Results: The overall sustained virological response (SVR), defined as undetectable HCV RNA in serum, 24 wk after the end of treatment, was remarkably high by 84.4%, (146/173) by an intention-to-treat analysis. A significant difference in SVR was found between patients with and without the discontinuation of ribavirin (46.9% vs 92.9%), but no difference was found between those with and without a dose reduction of ribavirin. A significant difference in SVR was also found between patients with less than 16 wk and patients with 16 or more weeks of ribavirin treatment (34.8% vs 92.0%). Conclusion: The 24-wk interferon and ribavirin treatment is highly effective for Japanese patients with HCV genotype 2. The significant predictor of SVR is continuation of the ribavirin treatment for up to 16 weeks.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalWorld Journal of Gastroenterology
Volume12
Issue number5
DOIs
Publication statusPublished - Feb 7 2006

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Ribavirin
Chronic Hepatitis C
Interferon-alpha
Hepacivirus
Liver Diseases
Genotype
Therapeutics
Intention to Treat Analysis
Interferons
RNA
Serum

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2 : A project of the Kyushu University Liver Diseases Study Group. / Furusyo, Norihiro; Katoh, Masaki; Tababe, Yuichi; Kajiwara, Eiji; Maruyama, Toshihiro; Shimono, Junya; Sakai, Hironori; Nakamuta, Makoto; Nomura, Hideyuki; Masumoto, Akihide; Shimoda, Shinji; Takahashi, Kazuhiro; Azuma, Koichi; Hayashi, Jun; Nakashima, H.; Murata, M.; Toyoda, K.; Takeoka, H.; Kuga, T.; Mitsutake, A.; Sugimoto, R.; Amagase, H.; Tominaga, S.; Yanagita, K.; Ogiwara, K.; Tokumatsu, M.; Tabata, S.; Yokota, M.; Tanaka, H.; Nagase, S.; Tsuruta, S.; Tada, S.; Nagano, M.; Honda, M.; Umeno, T.; Sugimura, T.; Ueno, S.; Miki, K.; Okubo, H.; Fujimoto, H.; Higuchi, N.; Shigematsu, S.; Higashi, N.

In: World Journal of Gastroenterology, Vol. 12, No. 5, 07.02.2006, p. 784-790.

Research output: Contribution to journalArticle

Furusyo, N, Katoh, M, Tababe, Y, Kajiwara, E, Maruyama, T, Shimono, J, Sakai, H, Nakamuta, M, Nomura, H, Masumoto, A, Shimoda, S, Takahashi, K, Azuma, K, Hayashi, J, Nakashima, H, Murata, M, Toyoda, K, Takeoka, H, Kuga, T, Mitsutake, A, Sugimoto, R, Amagase, H, Tominaga, S, Yanagita, K, Ogiwara, K, Tokumatsu, M, Tabata, S, Yokota, M, Tanaka, H, Nagase, S, Tsuruta, S, Tada, S, Nagano, M, Honda, M, Umeno, T, Sugimura, T, Ueno, S, Miki, K, Okubo, H, Fujimoto, H, Higuchi, N, Shigematsu, S & Higashi, N 2006, 'Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2: A project of the Kyushu University Liver Diseases Study Group', World Journal of Gastroenterology, vol. 12, no. 5, pp. 784-790. https://doi.org/10.3748/wjg.v12.i5.784
Furusyo, Norihiro ; Katoh, Masaki ; Tababe, Yuichi ; Kajiwara, Eiji ; Maruyama, Toshihiro ; Shimono, Junya ; Sakai, Hironori ; Nakamuta, Makoto ; Nomura, Hideyuki ; Masumoto, Akihide ; Shimoda, Shinji ; Takahashi, Kazuhiro ; Azuma, Koichi ; Hayashi, Jun ; Nakashima, H. ; Murata, M. ; Toyoda, K. ; Takeoka, H. ; Kuga, T. ; Mitsutake, A. ; Sugimoto, R. ; Amagase, H. ; Tominaga, S. ; Yanagita, K. ; Ogiwara, K. ; Tokumatsu, M. ; Tabata, S. ; Yokota, M. ; Tanaka, H. ; Nagase, S. ; Tsuruta, S. ; Tada, S. ; Nagano, M. ; Honda, M. ; Umeno, T. ; Sugimura, T. ; Ueno, S. ; Miki, K. ; Okubo, H. ; Fujimoto, H. ; Higuchi, N. ; Shigematsu, S. ; Higashi, N. / Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2 : A project of the Kyushu University Liver Diseases Study Group. In: World Journal of Gastroenterology. 2006 ; Vol. 12, No. 5. pp. 784-790.
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abstract = "Aim: To determine the efficacy of an interferon alpha and ribavirin combination treatment for Japanese patients infected with hepatitis C virus (HCV) of genotype 2, a multi-center study was retrospectively analyzed. Methods: In total, 173 patients with HCV genotype 2 started to receive interferon-alpha subcutaneously thrice a week and 600-800 mg of ribavirin daily for 24 wk. Results: The overall sustained virological response (SVR), defined as undetectable HCV RNA in serum, 24 wk after the end of treatment, was remarkably high by 84.4{\%}, (146/173) by an intention-to-treat analysis. A significant difference in SVR was found between patients with and without the discontinuation of ribavirin (46.9{\%} vs 92.9{\%}), but no difference was found between those with and without a dose reduction of ribavirin. A significant difference in SVR was also found between patients with less than 16 wk and patients with 16 or more weeks of ribavirin treatment (34.8{\%} vs 92.0{\%}). Conclusion: The 24-wk interferon and ribavirin treatment is highly effective for Japanese patients with HCV genotype 2. The significant predictor of SVR is continuation of the ribavirin treatment for up to 16 weeks.",
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T1 - Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2

T2 - A project of the Kyushu University Liver Diseases Study Group

AU - Furusyo, Norihiro

AU - Katoh, Masaki

AU - Tababe, Yuichi

AU - Kajiwara, Eiji

AU - Maruyama, Toshihiro

AU - Shimono, Junya

AU - Sakai, Hironori

AU - Nakamuta, Makoto

AU - Nomura, Hideyuki

AU - Masumoto, Akihide

AU - Shimoda, Shinji

AU - Takahashi, Kazuhiro

AU - Azuma, Koichi

AU - Hayashi, Jun

AU - Nakashima, H.

AU - Murata, M.

AU - Toyoda, K.

AU - Takeoka, H.

AU - Kuga, T.

AU - Mitsutake, A.

AU - Sugimoto, R.

AU - Amagase, H.

AU - Tominaga, S.

AU - Yanagita, K.

AU - Ogiwara, K.

AU - Tokumatsu, M.

AU - Tabata, S.

AU - Yokota, M.

AU - Tanaka, H.

AU - Nagase, S.

AU - Tsuruta, S.

AU - Tada, S.

AU - Nagano, M.

AU - Honda, M.

AU - Umeno, T.

AU - Sugimura, T.

AU - Ueno, S.

AU - Miki, K.

AU - Okubo, H.

AU - Fujimoto, H.

AU - Higuchi, N.

AU - Shigematsu, S.

AU - Higashi, N.

PY - 2006/2/7

Y1 - 2006/2/7

N2 - Aim: To determine the efficacy of an interferon alpha and ribavirin combination treatment for Japanese patients infected with hepatitis C virus (HCV) of genotype 2, a multi-center study was retrospectively analyzed. Methods: In total, 173 patients with HCV genotype 2 started to receive interferon-alpha subcutaneously thrice a week and 600-800 mg of ribavirin daily for 24 wk. Results: The overall sustained virological response (SVR), defined as undetectable HCV RNA in serum, 24 wk after the end of treatment, was remarkably high by 84.4%, (146/173) by an intention-to-treat analysis. A significant difference in SVR was found between patients with and without the discontinuation of ribavirin (46.9% vs 92.9%), but no difference was found between those with and without a dose reduction of ribavirin. A significant difference in SVR was also found between patients with less than 16 wk and patients with 16 or more weeks of ribavirin treatment (34.8% vs 92.0%). Conclusion: The 24-wk interferon and ribavirin treatment is highly effective for Japanese patients with HCV genotype 2. The significant predictor of SVR is continuation of the ribavirin treatment for up to 16 weeks.

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